Real time electronic cell sensing systems and applications for cell-based assays
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Accused Products
Abstract
The present invention includes devices, systems, and methods for assaying cells using cell-substrate impedance monitoring. In one aspect, the invention provides cell-substrate impedance monitoring devices that comprise electrode arrays on a nonconducting substrate, in which each of the arrays has an approximately uniform electrode resistance across the entire array. In another aspect, the invention provides cell-substrate monitoring systems comprising one or more cell-substrate monitoring devices comprising multiple wells each having an electrode array, an impedance analyzer, a device station that connects arrays of individual wells to the impedance analyzer, and software for controlling the device station and impedance analyzer. In another aspect, the invention provides cellular assays that use impedance monitoring to detect changes in cell behavior or state. In some preferred aspects, the assays are designed to investigate the affects of compounds on cells, such as cytotoxicity assays. In other preferred aspects, the assays are designed to investigate the compounds that effect IgE-mediated responses of cells to antigens.
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Citations
104 Claims
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1-50. -50. (canceled)
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51. A system for monitoring cell-substrate impedance, comprising:
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a) one or more multiple well cell-substrate impedance monitoring devices, wherein at least two of the multiple wells of said device comprise an electrode array at the bottom of the well, wherein said electrode array is individually addressed, further wherein said device can be used to measure differences in impedance values that relate to cell behavior;
b) an impedance analyzer;
c) a device station comprising electronic circuitry that can engage said device and selectively connect said two or more electrode arrays of said device to said impedance analyzer; and
d) a software program that can said control device station and record and analyze data obtained from said impedance analyzer. - View Dependent Claims (52, 53, 54, 55, 56, 57, 58, 59, 60, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 101, 102, 103)
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61-71. -71. (canceled)
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82-100. -100. (canceled)
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104-159. -159. (canceled)
Specification