Cell adhesion resisting surfaces
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Accused Products
Abstract
A coated surface that resists cell adhesion comprises hyaluronic acid directly bound to a plasma-treated polymer surface. A process for producing the coated surface is disclosed as are further modifications of the hyaluronic acid by attaching ligand-binding polypeptides (antibodies or antibody binding proteins).
27 Citations
98 Claims
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1-58. -58. (canceled)
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59. A process of coating a surface of an article with hyaluronic acid (HA) or alginic acid (AA) or a derivative of HA or AA, which consists essentially of the steps of
i) treating a surface of an article with a plasma that causes formation of nitrogen containing groups on said surface; - and
ii) exposing the treated surface of the article to a solution containing hyaluronic acid or alginic acid, or a derivative thereof, in the presence of a carbodiimide and a reactive intermediate ester stabilizing compound;
to obtain a coated surface. - View Dependent Claims (60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98)
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70. A process of coating a plasma-treated surface of an article, which surface comprises nitrogen-containing groups, with HA or AA or a derivative of HA or AA, said process comprising:
exposing the plasma-treated surface to a solution of HA, AA or said derivative in the presence of a carbodiimide and a reactive intermediate stabilizing compound, to obtain a coated surface. - View Dependent Claims (71, 72, 73, 74, 75, 76, 77, 78, 79)
Specification