Antiviral oligonucleotides targeting viral families
First Claim
1. A method for the prophylaxis or treatment of a viral infection in a subject, comprising administering to a subject in need of such treatment a therapeutically effective amount of at least one pharmacologically acceptable oligonucleotide at least 10 nucleotides in length, wherein the anti-viral activity of said oligonucleotide occurs principally by a non-sequence complementary mode of action, and wherein the virus is different from HIV-1, HIV-2, HSV-1, HSV-2, CMV, RSV, parainfluenza virus, and HBV.
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Abstract
Random sequence oligonucleotides that have antiviral activity are described, along with their use as antiviral agents. In many cases, the oligonucleotides are greater than 40 nucleotides in length. Also described are methods for the prophylaxis or treatment of a viral infection in a human or animal, and a method for the prophylaxis treatment of cancer caused by oncoviruses in a human or animal. The methods typically involve administering to a human or animal in need of such treatment, a pharmacologically acceptable, therapeutically effective amount of at least oligonucleotide that does not act by a sequence complementary mode of action.
68 Citations
57 Claims
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1. A method for the prophylaxis or treatment of a viral infection in a subject, comprising
administering to a subject in need of such treatment a therapeutically effective amount of at least one pharmacologically acceptable oligonucleotide at least 10 nucleotides in length, wherein the anti-viral activity of said oligonucleotide occurs principally by a non-sequence complementary mode of action, and wherein the virus is different from HIV-1, HIV-2, HSV-1, HSV-2, CMV, RSV, parainfluenza virus, and HBV.
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22. An antiviral pharmaceutical composition comprising
a therapeutically effective amount of at least one pharmacologically acceptable, antiviral oligonucleotide at least 10 nucleotides in length, wherein said composition is approved for use in humans against a target virus, and the antiviral activity of said oligonucleotide occurs principally by a non-sequence complementary mode of action, and said target virus is different from HIV-1, HIV-2, HSV-1, HSV-2, CMV, RSV, parainfluenza virus, and HBV; - and
a pharmaceutically acceptable carrier. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30)
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- 31. A kit comprising at least one anti-viral oligonucleotide or anti-viral oligonucleotide formulation in a labeled package, wherein said oligonucleotide is at least 10 nucleotides in length, the anti-viral activity of said oligonucleotide occurs principally by a non-sequence complementary mode of action, and the label on said package indicates that said anti-viral oligonucleotide can be used against a target virus different from HIV-1, HIV-2, HSV-1, HSV-2, CMV, RSV, parainfluenza virus, and HBV.
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52. A method for selecting an antiviral oligonucleotide for use as an anti-viral agent against a target virus different from HIV-1, HIV-2, HSV-1, HSV-2, CMV, RSV, parainfluenza virus, and HBV, comprising
synthesizing a plurality of different oligonucleotides, wherein at least one of said different oligonucleotides is at least 10 nucleotides in length; -
testing said oligonucleotides for activity in inhibiting the ability of said target virus to produce infectious virions, selecting a said oligonucleotide having a pharmaceutically acceptable level of activity for use as an anti-viral agent. - View Dependent Claims (53, 54, 55, 56)
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57. A method for the prophylaxis or treatment of a viral infection in a subject, comprising
administering to a subject in need of such treatment a therapeutically effective amount of at least one pharmacologically acceptable oligonucleotide randomer at least 10 nucleotides in length, wherein the anti-viral activity of said randomer occurs principally by a non-sequence complementary mode of action, wherein the virus is different from HIV-1, HIV-2, HSV-1, HSV-2, CMV, RSV, parainfluenza virus, and HBV.
Specification