INTEGRATED RECEIVER FOR CONTINUOUS ANALYTE SENSOR

• US 20050154271A1
• Filed: 11/17/2004
• Published: 07/14/2005
• Est. Priority Date: 11/19/2003
• Status: Active Grant

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Rasdal, Andrew, Simpson, Peter C., Brauker, James, Neale, Paul
• Granted Patent: US 7,519,408 B2
• Time in Patent Office: Days
• US Class Current: 600/347
• CPC Class Codes: A61B 2560/0456 Apparatus provided with a docking unit
• CPC Class Codes: A61B 2562/247 Hygienic covers, i.e. for covering the sensor or apparatus during use
• CPC Class Codes: A61B 5/076 Permanent implantations telemetry using implanted circuitry A61B5/0031; implanted stimulators for therapy A61N1/3605, A61N1/362, A61N1/372
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal

Abstract

Abstract of the Disclosure

A system is provided for monitoring glucose in a host, including a continuous glucose sensor that produces a data stream indicative of a host’s glucose concentration and an integrated receiver that receives the data stream from the continuous glucose sensor and calibrates the data stream using a single point glucose monitor that is integral with the integrated receiver. The integrated receiver obtains a glucose value from the single point glucose monitor, calibrates the sensor data stream received from the continuous glucose sensor, and displays one or both of the single point glucose measurement values and the calibrated continuous glucose sensor values on the user interface.

Claims

1. A device for monitoring glucose concentration in a biological sample of a host, the device comprising:

2. The device of claim 1, wherein the continuous glucose sensor comprises:

3. The device of claim 2, wherein the single point glucose monitor comprises:

4. The device of claim 1, wherein the integrated receiver further comprises a user interface for displaying glucose concentration data from at least one of the continuous glucose sensor and the single point glucose monitor.

5. A method for calibrating a continuous glucose sensor in an integrated receiver, the method comprising:

6. The method of claim 5, further comprising the step of:

displaying the glucose concentration measured by the single point glucose monitor.

7. The method of claim 5, further comprising the step of:

displaying a calibrated data stream.

8. A device for calibrating continuous glucose sensor data, the device comprising:

9. The device of claim 8, wherein the continuous glucose sensor comprises:

10. The device of claim 9, wherein the single point glucose monitor comprises:

11. The device of claim 8, further comprising a user interface adapted to display glucose data from at least one of the continuous glucose sensor and the single point glucose monitor.

12. The device of claim 8, wherein the glucose monitor comprises a sensing region comprising a sensing membrane and at least two electrodes, wherein the sensing region is located within the integrated receiver.

13. The device of claim 12, wherein the integrated receiver comprises a removable cartridge, and wherein the sensing region is located within the removable cartridge.

14. The device of claim 8, wherein the integrated receiver comprises a housing, and wherein the glucose monitor comprises a sensing region movably mounted to the integrated receiver housing.

15. The device of claim 14, further comprising a stylus movably mounted to the integrated receiver housing, and wherein the sensing region is located on the stylus.

16. The device of claim 14, further comprising a receiving chamber located within the integrated receiver housing, and wherein the stylus is received within the receiving chamber for storage.

17. The device of claim 16, further comprising a sterile solution chamber located at an end of the receiving chamber such that the sensing region is operably associated with the sterile solution chamber when the stylus is received within the receiving chamber for storage.

18. The device of claim 17, further comprising a sterile solution port configured for refilling the sterile solution chamber with a sterile solution.

19. The device of claim 14, further comprising a dispensing chamber located in the integrated receiver housing, the dispensing chamber adapted to dispense at least one disposable bioprotective film onto the sensing region.

20. The device of claim 19, further comprising a storage chamber located in the integrated receiver housing, the storage chamber adapted to store the disposable bioprotective film.

21. The device of claim 19, further comprising a shuttle mechanism located on the integrated receiver housing, the shuttle mechanism adapted to load the disposable bioprotective film into the dispensing chamber.

22. The device of claim 14, further comprising at least one bioprotective film that is adapted to stretch or stick onto the sensing region to protect the sensing region from damage, clogging, or contamination from a biological fluid.

23. The device of claim 22, wherein the bioprotective film further comprises a sensing membrane comprising an enzyme.

24. The device of claim 14, wherein the sensing region comprises a sensing membrane and at least two electrodes, wherein the sensing membrane is disposed over the electrodes adapted for measuring a glucose concentration in a biological sample.

25. The device of claim 8, wherein the single point glucose monitor comprises a sensor port that houses a sensing region adapted for measuring a glucose concentration in the biological sample.

26. The device of claim 24, further comprising a disposable capillary tube, wherein the capillary tube is configured to create a capillary action capable of drawing a liquid biological sample from a first end of the tube to a second end of the tube.

27. The device of claim 25, wherein the capillary tube comprises a filter configured to permit passage of glucose, but to filter or block passage of an undesired species or a contaminating species in the biological sample.

28. The device of claim 26, wherein the capillary tube further comprises a vent configured to allow displaced air within the capillary tube to escape therefrom.

29. The device of claim 24, wherein the sensor port comprises a cover adapted for protecting the sensing region.

30. The device of claim 24, wherein the disposable capillary tube comprises a sensing membrane, wherein the sensing membrane comprises a resistance domain, an enzyme domain, an interference domain, and an electrolyte domain.

31. The device of claim 8, wherein the single point glucose monitor and the receiver are detachably connected to each other.

32. The device of claim 31, wherein the single point glucose monitor and the receiver each comprise at least one contact adapted for operable connection when detachably connected to each other.

33. The device of claim 31, wherein the microprocessor is located within the receiver.

34. The device of claim 31, further comprising a microprocessor located within the single point glucose monitor, wherein the microprocessor is adapted for communication between the single point glucose monitor and the receiver when the single point glucose monitor contact and the receiver contact are operably connected.

35. A device for monitoring a glucose concentration in a biological sample in a host, the device comprising: