Method and system for providing therapy for neuropsychiatric and neurological disorders utilizing transcranical magnetic stimulation and pulsed electrical vagus nerve(s) stimulation
First Claim
1. A method of providing electrical pulses to vagus nerve(s), and/or its branches or part thereof in a patient, and transcranial magnetic stimulation for treating or alleviating the symptoms of neurological disorders, neuropsychiatric, and cognitive impairments, comprising the steps of:
- a) selecting a patient, wherein said patient is a transcranial magnetic stimulation recipient, and b) providing electrical pulses to vagus nerve(s), and/or its branches or part thereof, whereby, said patient receives said transcranial magnetic stimulation and vagus nerve electrical stimulation.
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Accused Products
Abstract
A method and system of providing therapy or alleviating the symptoms of neuropsychiatric disorders and cognitive impairments comprises, providing repetitive transcranial magnetic stimulation (rTMS) to the brain and pulsed electrical stimulation to the vagus nerve(s) for afferent neuromodulation. These neuropsychiatric disorders and cognitive impairments include depression, bipolar depression, anxiety disorders, obsessive-compulsive disorders, schizophrenia, borderline personality disorders, sleep disorders, learning difficulties, memory impairments and the like. rTMS is provided to the brain via external coil which may be either circular in shape or figure-eight shaped. The frequency of TMS may be 1 Hz, 5 Hz, 20 Hz, or 60 Hz. RTMS may be provided via square pulses or sine wave pulses. Pulsed electrical stimulation to the vagus nerve(s) may be provided continuously in ON-OFF repeating cycles. The two stimulation therapies may be given in any order, any combination, or any sequence as determined by the physician. The two stimulation therapies may also be used with or without pharmaceutical therapy. Pulsed electrical vagus nerve stimulation (VNS) may be provided using an implanted pulse generator (IPG) or an external stimulator used in conjunction with an implanted stimulus-receiver. In one aspect of the invention the pulse generator system may comprise communication capabilities for networking over a wide area network, for remote interrogation and programming.
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Citations
21 Claims
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1. A method of providing electrical pulses to vagus nerve(s), and/or its branches or part thereof in a patient, and transcranial magnetic stimulation for treating or alleviating the symptoms of neurological disorders, neuropsychiatric, and cognitive impairments, comprising the steps of:
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a) selecting a patient, wherein said patient is a transcranial magnetic stimulation recipient, and b) providing electrical pulses to vagus nerve(s), and/or its branches or part thereof, whereby, said patient receives said transcranial magnetic stimulation and vagus nerve electrical stimulation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method of providing a combination of magnetic stimulation and electrical stimulation and/or nerve blocking therapy to a patient for treating, controlling, or alleviating the symptoms for at least one of depression, bipolar depression, unipolar depression, severe depression, treatment resistant depression, melancholia, schizophrenia, anxiety disorders, mood disorders, obsessive compulsive disorders, dementia including Alzheimer'"'"'s disease, sleep disorders, borderline personality disorders learning difficulties, and memory impairments, comprising the steps of:
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a) selecting a patient for providing said therapy;
b) providing transcranial magnetic stimulation to said patient; and
c) providing electrical pulses to vagus nerve(s), and/or its branches or part thereof in said patient. - View Dependent Claims (11, 12, 13)
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14. A method of modulationg the brain activity for treating or alleviating the symptoms for at least one of neurological disorders, neuropsychiatric disorders, and cognitive impairments, comprising the steps of:
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a) providing a means to provide transcranial magnetic stimulation to alter the brain activity from outside the patient body, and b) providing a means to provide electric pulses to vagus nerve(s), and/or its branches, or parts thereof, to alter the brain activity from inside the patient body. - View Dependent Claims (15, 16, 17)
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18. A system of providing transcranial magnetic pulses and electric pulses to the vagus nerve(s), in a patient for treating or alleviating the symptoms for at least one of neurological disorders, neuropsychiatric disorders, and cognitive impairments, comprising:
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a) a means for providing transcranial magnetic pulses, wherein said means comprises a means for generating repetitive magnetic pulses, and coils for delivering said pulses to brain of said patient;
b) a means for providing electrical pulses to vagus nerve(s) in a patient, wherein said means comprises implantable and external components. - View Dependent Claims (19, 20, 21)
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Specification