Methods, program products, and systems for single and multi-agent dosing and other related methods
First Claim
1. A method for revising a cycle dose of at least one agent in a therapy for a patient receiving such a therapy, the method comprising the steps of:
- accepting as a first input the patient'"'"'s cycle dose of the at least one agent;
accepting as a second input determination of the relevancy of at least one surrogate marker indicating a pharmacologic response of the patient; and
determining a revised cycle dose of the at least one agent as a function of the first input cycle dose and second input determination of the relevancy of the at least one surrogate marker.
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Accused Products
Abstract
Methods, program product, and systems for single and multi-agent dosing are provided. An embodiment of a method for revising a cycle dose of at least one agent for a patient receiving a single or multi-agent therapy includes accepting as a first input the patient'"'"'s cycle dose(s) of the at least one agent, accepting as a second input determination of the relevancy of at least one surrogate marker indicating a pharmacologic response of the patient and determining a revised dose of the at least one agent. Embodiments of systems and program products are also provided for use in calculating revised dose of at least one agent.
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Citations
22 Claims
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1. A method for revising a cycle dose of at least one agent in a therapy for a patient receiving such a therapy, the method comprising the steps of:
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accepting as a first input the patient'"'"'s cycle dose of the at least one agent;
accepting as a second input determination of the relevancy of at least one surrogate marker indicating a pharmacologic response of the patient; and
determining a revised cycle dose of the at least one agent as a function of the first input cycle dose and second input determination of the relevancy of the at least one surrogate marker. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method for revising a cycle dose of at least one agent in a therapy for a patient receiving such a therapy, the method comprising the steps of:
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accepting as a first input the patient'"'"'s cycle dose of the at least one agent;
accepting as a second input at least one non-pharmacologic modality received by the patient;
accepting as a third input determination of the relevancy of at least one surrogate marker indicating a pharmacologic response of the patient;
accepting as a fourth input determination of the relevancy of the at least one non-pharmacologic modality indicating achievement of maximum benefit; and
determining a revised cycle dose of the at least one agent responsive to the cumulative effect of the at least one agent and the at least one non-pharmacologic modality to be achieved by the therapy and non-pharmacologic intervention, the revised cycle dose being a function of the first input cycle dose, the at least one non-pharmacologic modality, determination of the relevancy of the at least one surrogate marker and determination of the relevancy of the at least one non-pharmacologic modality. - View Dependent Claims (8)
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9. A system to calculate a revised cycle dose of at least one agent in a therapy for a patient receiving such a therapy, the system comprising:
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means for accepting as a first input the patient'"'"'s cycle dose of the at least one agent;
means for accepting as a second input determination of the relevancy of at least one surrogate marker indicating a pharmacologic response of the patient; and
means responsive to the first input and second input for calculating a revised cycle dose of the at least one agent. - View Dependent Claims (10, 11, 12)
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13. A system to calculate a revised cycle dose of at least one agent in a therapy for a patient receiving such a therapy, the system comprising:
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means for accepting as a first input the patient'"'"'s cycle dose of the at least one agent;
means for accepting as a second input at least one non-pharmacologic modality received by the patient;
means for accepting as a third input determination of the relevancy of at least one surrogate marker indicating a pharmacologic response of the patient;
means for accepting as a fourth input determination of the relevancy of the at least one non-pharmacologic modality indicating achievement of maximum benefit; and
means responsive to the first, second, third and fourth inputs for calculating a revised cycle dose of the at least one agent as a function of the first input cycle dose, the at least one non-pharmacologic modality, determination of the relevancy of the at least one surrogate marker and determination of the relevancy of the at least one non-pharmacologic modality. - View Dependent Claims (14)
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15. A program product stored on a tangible computer memory medium to calculate a revised cycle dose of at least one agent in a therapy for a patient receiving such a therapy, the program product comprising:
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means for accepting as a first input the patient'"'"'s cycle dose of the at least one agent;
means for accepting as a second input determination of the relevancy of at least one surrogate marker indicating a pharmacologic response of the patient; and
means responsive to the effect of the at least one agent to be achieved by the therapy for calculating a revised cycle dose of the at least one agent as a function of the first input cycle dose and second input determination of the relevancy of the at least one surrogate marker. - View Dependent Claims (16)
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17. A program product stored on a tangible computer memory medium to calculate a revised cycle dose of at least one agent in a therapy for a patient receiving such a therapy, the program product comprising:
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means for accepting as a first input the patient'"'"'s cycle dose of the at least one agent;
means for accepting as a second input at least one non-pharmacologic modality received by the patient;
means for accepting as a third input determination of the relevancy of at least one surrogate marker indicating a pharmacologic response of the patient;
means for accepting as a fourth input determination of the relevancy of the at least one non-pharmacologic modality indicating achievement of maximum benefit; and
means responsive to the cumulative effect of the at least one agent and the at least one non-pharmacologic modality to be achieved by the therapy and non-pharmacologic intervention for calculating a revised cycle dose of the at least one agent as a function of the first input cycle dose(s), the at least one non-pharmacologic modality, determination of the relevancy of the at least one surrogate marker and determination of the relevancy of the at least one non-pharmacologic modality. - View Dependent Claims (18)
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19. A program product stored on a tangible computer memory medium to calculate a revised cycle dose of at least one agent in a therapy for a patient receiving such a therapy, the program product comprising:
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a first receiver to accept as a first input the patient'"'"'s cycle dose(s) of the at least one agent;
a second receiver to accept as a second input determination of the relevancy of at least one surrogate marker indicating a pharmacologic response of the patient; and
a calculator to calculate a revised cycle dose of the at least one agent as a function of the first input cycle dose and second input determination of the relevancy of the at least one surrogate marker in response to the effect of the at least one agent to be achieved by the therapy. - View Dependent Claims (20)
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21. A program product stored on a tangible computer memory medium to calculate a revised cycle dose of at least one agent in a therapy for a patient receiving such a therapy, the program product comprising:
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a first receiver to accept as a first input the patient'"'"'s cycle dose of the at least one agent;
a second receiver to accept as a second input at least one non-pharmacologic modality received by the patient;
a third receiver to accept as a third input determination of the relevancy of at least one surrogate marker indicating a pharmacologic response of the patient;
a fourth receiver to accept as a fourth input determination of the relevancy of the at least one non-pharmacologic modality indicating achievement of maximum benefit; and
a calculator to calculate a revised cycle dose of the at least one agent as a function of the first input cycle dose, the at least one non-pharmacologic modality, determination of the relevancy of the at least one surrogate marker and determination of the relevancy of the at least one non-pharmacologic modality in response to the cumulative effect of the at least one agent and the at least one non-pharmacologic modality to be achieved by the therapy and non-pharmacologic intervention. - View Dependent Claims (22)
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Specification