Novel oligonucleotides and related compounds
First Claim
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19. The oligonucleotide of claim 19, wherein the alkyl is methyl.
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Abstract
The present invention relates generally to oligonucleotides and more specifically to oligonucleotides which have a sequence including at least two CDG dinucleotides and a prodrug of an antimetabolite. The prodrug can be part of a CpG dinucleotide or may be attached elsewhere on the oligonucleotide.
35 Citations
44 Claims
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19. The oligonucleotide of claim 19, wherein the alkyl is methyl.
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23. An oligonucleotide for preferentially killing cancerous cells over non-cancerous cells comprising a motif represented by the formula:
- 5′
PGXCG3′
wherein P is a prodrug for an antimetabolite and X represents between 0 and 50 nucleotides. - View Dependent Claims (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 20, 21, 22, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 39)
- 5′
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29-1. The oligonucleotide of claim 23, wherein the oligonucleotide comprises multiple nucleotides and the prodrug is covalently linked to one of the nucleotides by a 3′
- -5′
linkage.
- -5′
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38. A compound having purity in excess of 98% by HPLC, having the formula:
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40. group consisting of a C1-C6 alkyl, ethyloxyglycol, and a combination of alkyl and ethyleneglycoxy.
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41. A compound having the formula:
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42. A compound of the formula:
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43. A compound having a purity in excess of 97% by HPLC, as shown by the formula:
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44. A compound having purity in excess of 97% by HPLC, and having the formula:
Specification