Transgenically produced decorin

• US 20050160483A1
• Filed: 12/14/2004
• Published: 07/21/2005
• Est. Priority Date: 05/05/2000
• Status: Abandoned Application

• Current Assignee: GTC Biotherapeutics, Inc.
• Original Assignee: GTC Biotherapeutics, Inc.
• Inventors: Pierschbacher, Michael, Meade, Harry M.
• Application Number:
  US11/011,927
• Publication Number:
  US 20050160483A1
• Time in Patent Office: Days
• US Class Current: 800/6
• CPC Class Codes: A01K 2217/05 Animals comprising random inserted nucleic acids (transgenic)
• CPC Class Codes: A01K 2227/102 Caprine
• CPC Class Codes: A01K 2227/105 Murine
• CPC Class Codes: A01K 2267/01 Animal expressing industrially exogenous proteins
• CPC Class Codes: A01K 67/0275 Genetically modified vertebrates, e.g. transgenic
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: C07K 14/4725 Proteoglycans, e.g. aggreccan
• CPC Class Codes: C12N 15/8509 for producing genetically modified animals, e.g. transgenic

Abstract

Transgenically produced decorin and methods of making and using transgenically produced decorin.

Claims

1. A transgenically produced preparation of decorin.

2. The preparation of claim 1, wherein said decorin is human decorin.

3. The preparation of claim 1, wherein said decorin is produced in a transgenic animal.

4. The preparation of claim 1, wherein said decorin is produced in a transgenic mammal.

5. The preparation of claim 1, wherein said decorin is produced in a transgenic dairy animal.

6. The preparation of claim 1, wherein said decorin is produced in a transgenic goat.

7. The preparation of claim 1, wherein the transgenically produced decorin lacks a GAG chain.

8. The preparation of claim 1, wherein the transgenically produced decorin is made in a mammary gland of a transgenic mammal

9. A transgenically produced preparation of decorin, wherein less than 30% of the decorin molecules in the preparation have a GAG chain.

10-19. -19. (canceled)

20. A pharmaceutical composition comprising a therapeutically effective amount of transgenic decorin or a transgenic preparation of decorin and a pharmaceutically acceptable carrier.

21. A formulation, which includes a transgenically produced human decorin and at least one other nutritional component.

22. A pharmaceutical composition comprising a therapeutically effective amount of transgenic decorin or a transgenic preparation of decorin and a pharmaceutically acceptable carrier.

23. A formulation, which includes a transgenically produced human decorin and at least one other nutritional component.