Compositions and dosage forms for enhanced absorption of iron
First Claim
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1. A substance comprised of iron and a transport moiety, the iron and the transport moiety forming a complex.
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Abstract
A complex comprised of iron and a transport moiety, such as a fatty acid, is described. The complex has an enhanced absorption in the gastrointestinal tract, particularly the lower gastrointestinal tract. The complex, and compositions and dosage forms prepared using the complex, provide for absorption by the body of iron through a period of ten to twenty-four hours, thus enabling a true once-daily dosage form for iron.
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34 Claims
- 1. A substance comprised of iron and a transport moiety, the iron and the transport moiety forming a complex.
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4. A composition, comprising,
a complex consisting essentially of iron and a transport moiety, and a pharmaceutically acceptable vehicle, wherein said complex has an absorption in the lower gastrointestinal tract at least 2 fold higher than ferrous sulfate.
- 14. An improvement in a dosage form comprising iron, the improvement comprising a dosage form comprising a complex comprised of iron and a transport moiety.
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19. A method of preparing an iron-transport moiety complex, comprising
providing iron; -
providing a transport moiety;
combining the iron and the transport moiety in the presence of a solvent having a dielectric constant less than that of water;
whereby said combining results in formation of a complex between the iron and the transport moiety. - View Dependent Claims (20, 21)
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22. A method of improving G.I. absorption of iron, comprising
providing a complex comprising iron and a transport moiety, and administering the complex to a patient.
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32. A substance comprising iron and a transport moiety, said substance prepared by a process of (i) providing iron;
- (ii) providing a transport moiety;
(iii) combining the iron and the transport moiety in the presence of a solvent having a dielectric constant less than that of water, where said combining forms a complex between iron and the transport moiety. - View Dependent Claims (33, 34)
- (ii) providing a transport moiety;
Specification