Novel human transporter proteins and polynucleotides encoding the same

• US 20050164251A1
• Filed: 11/22/2004
• Published: 07/28/2005
• Est. Priority Date: 06/14/2001
• Status: Abandoned Application

• Current Assignee: Boris Nepomnichy, Brian Mathur, Carl Johan Friddle, Turner C. Alexander Jr, Yi Hu
• Original Assignee: Boris Nepomnichy, Brian Mathur, Carl Johan Friddle, Turner C. Alexander Jr, Yi Hu
• Inventors: Nepomnichy, Boris, Hu, Yi, Friddle, Carl Johan, Mathur, Brian, Turner, C. Alexander Jr.
• Application Number:
  US10/994,758
• Publication Number:
  US 20050164251A1
• Time in Patent Office: Days
• US Class Current: 435/6
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: C07K 14/47 from mammals
• CPC Class Codes: C07K 14/705 Receptors; Cell surface antigens; Cell surface determinants tumour specific antigens C07K14/4748

Abstract

Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.

Claims

1. An isolated nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:

1 or SEQ ID NO;

2.

4. A recombinant expression vector comprising the isolated nucleic acid molecule of claim 1.

5. A host cell comprising the recombinant expression vector of claim 4.

2. An isolated nucleic acid molecule comprising a nucleotide sequence that:

(a) encodes the amino acid sequence shown in SEQ ID NO;

3 or SEQ ID NO;

4; and

(b) hybridizes under highly stringent conditions to the nucleotide sequence of SEQ ID NO;

1 or SEQ ID NO;

2, or the complement thereof.

3. An isolated nucleic acid molecule comprising a nucleotide sequence that encodes the amino acid sequence shown in SEQ ID NO:

3 or SEQ ID NO;

4.

6. A substantially isolated protein having the activity of the protein shown in SEQ ID NOS:

3 or 4, which is encoded by a nucleotide sequence that hybridizes to the complement of SEQ ID NO;

1 or SEQ ID NO;

2 under highly stringent conditions.

7. An isolated nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:

6, SEQ ID NO;

8, SEQ ID NO;

10 or SEQ ID NO;

12.

10. A recombinant expression vector comprising the isolated nucleic acid molecule of claim 7.

11. A host cell comprising the recombinant expression vector of claim 10.

12. The host cell of claim 11, wherein said cell is procaryotic.

13. The host cell of claim 11, wherein said cell is eucaryotic.

8. An isolated nucleic acid molecule comprising a nucleotide sequence that:

(c) encodes the amino acid sequence of SEQ ID NO;

7, SEQ ID NO;

9, SEQ ID NO;

ll or SEQ ID NO;

13; and

(d) hybridizes under highly stringent conditions to the nucleotide sequence of SEQ ID NO;

6, SEQ ID NO;

8, SEQ ID NO;

10 or SEQ ID NO;

12, or the complement thereof.

9. An isolated nucleic acid molecule comprising a nucleotide sequence that encodes the amino acid sequence shown in SEQ ID NO:

7, SEQ ID NO;

9, SEQ ID NO;

11 or SEQ ID NO;

13.

14. A substantially isolated protein having the activity of the protein shown in SEQ ID NO:

7, SEQ ID NO;

9, SEQ ID NO;

11 or SEQ ID NO;

13, which is encoded by a nucleotide sequence that hybridizes to the complement of SEQ ID NO;

6, SEQ ID NO;

8, SEQ ID NO;

10 or SEQ ID NO;

12 under highly stringent conditions.