Microfluidic chemostat
First Claim
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1. A chemostat comprising:
- a growth chamber having a plurality of compartments, wherein each of the compartments may be fluidly isolated from the rest of the growth chamber by one or more actuatable valves;
a nutrient supply-line to supply growth medium to the growth chamber; and
an output port to remove fluids from the growth chamber.
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Abstract
A chemostat that includes a growth chamber having a plurality of compartments, where each of the compartments may be fluidly isolated from the rest of the growth chamber by one or more actuatable valves. The chemostat may also include a nutrient supply-line to supply growth medium to the growth chamber, and an output port to remove fluids from the growth chamber. Also, a method of preventing biofilm formation in a growth chamber of a chemostat. The method may include the steps of adding a lysis agent to a isolated portion of the growth chamber, and reuniting the isolated portion with the rest of the growth chamber.
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Citations
26 Claims
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1. A chemostat comprising:
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a growth chamber having a plurality of compartments, wherein each of the compartments may be fluidly isolated from the rest of the growth chamber by one or more actuatable valves;
a nutrient supply-line to supply growth medium to the growth chamber; and
an output port to remove fluids from the growth chamber. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A chemostat chip comprising an array of chemostats, wherein each of the chemostats comprises:
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a growth chamber having a plurality of compartments, wherein each of the compartments may be fluidly isolated from the rest of the growth chamber by one or more actuatable valves;
a nutrient supply-line to supply growth medium to the growth chamber; and
an output port to remove fluids from the growth chamber. - View Dependent Claims (16, 17)
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18. A method of making a chemostat, the method comprising:
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forming a flow layer comprising a flow channel, wherein a growth chamber of the chemostat comprises the flow channel; and
coupling the flow layer between a first control layer and a second control layer, wherein each of the control layers comprises one or more control channels that can be actuatued to fluidly isolate a compartment of the flow channel. - View Dependent Claims (19, 20, 21)
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22. A method of preventing biofilm formation in a growth chamber of a chemostat, the method comprising:
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adding a lysis agent to a isolated portion of the growth chamber; and
reuniting the isolated portion with the rest of the growth chamber. - View Dependent Claims (23, 24, 25, 26)
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Specification