Treatment of cardiac tissue following myocardial infarction utilizing high intensity focused ultrasound
First Claim
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1. A method for reducing the debilitating effects of myocardial infarctions in a heart, said method comprising:
- targeting a region of interest of the heart by diagnostic imaging;
emitting without timing to the heart cycle or position, and in a continual manner, therapeutic ultrasound energy from an ultrasound radiating surface placed on the skin or in the esophagus;
focusing the emitted therapeutic ultrasound energy on the region of interest throughout the heart cycle; and
, producing sub-lethal or partially lethal tissue or cellular damage in the region of interest thereby inducing at least one of regeneration of myocardial cells and angiogenesis in the region of interest.
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Abstract
A noninvasive or minimally invasive treatment of infarct areas of the heart with High Intensity Focused Ultrasound (HIFU) emitted without respect to the timing or phase of the cardiac cycle, intended to remodel cardiac tissue by inducing angiogenesis and/or the formation of myocytes to improve cardiac function.
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13 Claims
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1. A method for reducing the debilitating effects of myocardial infarctions in a heart, said method comprising:
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targeting a region of interest of the heart by diagnostic imaging;
emitting without timing to the heart cycle or position, and in a continual manner, therapeutic ultrasound energy from an ultrasound radiating surface placed on the skin or in the esophagus;
focusing the emitted therapeutic ultrasound energy on the region of interest throughout the heart cycle; and
,producing sub-lethal or partially lethal tissue or cellular damage in the region of interest thereby inducing at least one of regeneration of myocardial cells and angiogenesis in the region of interest. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method for providing for non-invasive or minimally invasive treatment of myocardial infarction utilizing therapeutic ultrasound, emitted without respect to the timing or phase of the cardiac cycle, said method comprising:
inducing at least one of injury to cardiac cells, phase transitions, changes in the shape of cell proteins, and structural protein remodeling in a defined volume, whereby tissues regenerate over time in a manner which reduces the volume of the infarction and increases cardiac output. - View Dependent Claims (13)
Specification