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System, method and apparatus for causal implication analysis in biological networks

  • US 20050165594A1
  • Filed: 11/19/2004
  • Published: 07/28/2005
  • Est. Priority Date: 11/26/2003
  • Status: Active Grant
First Claim
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1. A software implemented method for hypothesizing a biological relationship in a biological system, the method comprising:

  • (a) providing a database of biological assertions comprising a multiplicity of nodes representative of biological elements, relationship descriptors describing relationships between nodes, and characterizing properties of said nodes and relationships;

    (b) selecting a target node in the database known from experimental observation to correspond to a biological element which increases in number or concentration, decreases in number or concentration, appears within, or disappears from a real biological system when it is perturbed; and

    (c) performing a backward logical simulation within said database from said target node through said relationship descriptors upstream along a path defined by potentially causative nodes to discern a node hypothetically responsible for the experimentally observed change in said target node.

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