Device and method for measuring constituents in blood

• US 20050168722A1
• Filed: 02/08/2003
• Published: 08/04/2005
• Est. Priority Date: 03/27/2002
• Status: Active Grant

• Current Assignee: MCC Gesellschaft Fur Diagnosesysteme In Medizin und Technik mbH & Company KG
• Original Assignee: MCC Gesellschaft Fur Diagnosesysteme In Medizin und Technik mbH & Company KG
• Inventors: Forstner, Klaus, Scholler, Bernd
• Granted Patent: US 7,095,491 B2
• Time in Patent Office: Days
• US Class Current: 356/39
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/7207 of noise induced by motion artifacts

Abstract

The method and device serve to measure a proportion of constituents in blood. To this end, electromagnetic radiation of different radiation wavelengths is directed through a tissue (9) containing blood vessels (1). At least a portion of the radiation exiting the vessel is detected using sensors, and a corresponding measured value derived therefrom is fed to an evaluating device. The evaluating device (10) is connected to at least two sensors (2, 3, 4) and has an analyzer (11) for determining a dispersion of radiation by evaluating the intensity of the radiation received by the individual sensors. An individual calibration determination is carried out by evaluating the angle-dependent dispersion and can be drawn upon for conducting a pulse spectroscopic determination of concentrations of substances.

Claims

1. Method for controlling a device for measuring quantitative proportions of blood constituents, in which electromagnetic radiation of different radiation frequencies is passed through a blood-containing vessel, and at least a portion of the radiation exiting the vessel is detected by sensors and fed to an evaluating device, wherein at least two radiation detection sensors (2, 3, 4) are positioned a certain distance apart and that the evaluating device is assigned a calibration characteristic curve, which is determined by an individual calibration measurement, in which at least one constant is used as the calibration criterion and is determined from at least one measurement variable (22) detected by the sensors (2, 3, 4).

2. Method in accordance with claim 1, wherein at least three sensors (2, 3, 4) are used.

3. Method in accordance with claim 1, wherein the measuring determination is performed in a multiplex operation.

4. Method in accordance with claim 1, wherein electromagnetic radiation in the optical frequency range is used.

5. Method in accordance with claim 1, wherein pulse spectroscopy is used for the measuring determination.

6. Method in accordance with claim 1, wherein spectrophotometry is used for the measuring determination.

7. Method in accordance with claim 1, wherein the spatial scattering of the radiation is determined by measurement technology.

8. Method in accordance with claim 1, wherein the scattering is determined by determining a radiation intensity that deviates from the primary irradiation direction.

9. Method in accordance with claim 1, wherein a periodic calibration is carried out during the performance of the measurement.

10. Method in accordance with claim 1, wherein the scattering is determined by the relationship between the amplitudes of the measured values of the individual sensors (2, 3, 4)

11. Method in accordance with claim 1, wherein an oxygen concentration of the blood is determined.

12. Method in accordance with claim 1, wherein a relative oxygen concentration of the blood is determined.

13. Method in accordance with claim 1, wherein an absolute oxygen concentration of the blood is determined.

14. Device for measuring quantitative proportions of blood constituents, which has at least one emission source for generating electromagnetic radiation and at least one sensor, which detects the transmitted portion of the radiation and is connected with an evaluating device, wherein the evaluating device (10) has at least two sensors (2, 3, 4) and that the evaluating device (10) has an analyzer (11) for determining the angle-dependent scattering of the radiation by evaluating the signals received from the individual sensors (2, 3, 4).

15. Device in accordance with claim 14, wherein at least three sensors (2, 3, 4) are connected to the evaluating device (10).

16. Device in accordance with claim 14, wherein at least two emission sources (5, 6, 7) are used.

17. Device in accordance with claim 14, wherein at least three emission sources (5, 6, 7) are used.

18. Device in accordance with claim 14, wherein at least one of the emission sources (5, 6, 7) is designed as a light-emitting diode.

19. Device in accordance with claim 14, wherein at least one of the emission sources (5, 6, 7) is designed as a laser diode.

20. Device in accordance with claim 14, wherein at least one of the sensors (2, 3, 4) is designed as a photodiode.

21. Device in accordance with claim 14, wherein the sensors (2, 3, 4) are spaced essentially equal distances apart relative to one another.