System and method for computing volumetric perfusion

• US 20050169420A1
• Filed: 03/31/2005
• Published: 08/04/2005
• Est. Priority Date: 11/26/2002
• Status: Active Grant

• Current Assignee: General Electric Company
• Original Assignee: General Electric Company
• Inventors: Edic, Peter Michael, Conry, Anne Marie, Vass, Melissa Liliane
• Granted Patent: US 7,054,405 B2
• Time in Patent Office: Days
• US Class Current: 378/4
• CPC Class Codes: A61B 6/032 Transmission computed tomography [CT]
• CPC Class Codes: A61B 6/481 involving the use of contrast agents
• CPC Class Codes: A61B 6/488 involving pre-scan acquisition
• CPC Class Codes: A61B 6/507 for determination of haemodynamic parameters, e.g. perfusion CT
• CPC Class Codes: A61B 6/5217 extracting a diagnostic or physiological parameter from medical diagnostic data
• CPC Class Codes: G16H 50/30 for calculating health indices; for individual health risk assessment
• CPC Class Codes: Y10S 378/901 Computer tomography program or processor

Abstract

A method for computing volumetric perfusion using a computed tomography imaging (CT) system is presented. The method includes irradiating a spatially dynamic object within a field of view of the computed tomography imaging system for requisite view angle positions of the gantry. Furthermore, the method includes operating the computed tomography imaging system in a continuous data acquisition mode to acquire projection data representative of the spatially dynamic object. In addition, the method includes processing the projection data to generate time-resolved projection data. Reconstructions are generated using the time-resolved projection data. Additionally, the method includes computing the volumetric perfusion in the spatially dynamic object using the reconstructed data. Computer-readable medium that afford functionality of the type defined by this method is also contemplated in conjunction with the present technique.

Claims

1. A method for computing volumetric perfusion using a computed tomography imaging system, the method comprising:

irradiating a spatially dynamic object within a field of view of the computed tomography imaging system for requisite view angle positions of the gantry;

operating the computed tomography imaging system in a continuous data acquisition mode to acquire projection data representative of the spatially dynamic object;

processing the projection data to generate time-resolved projection data;

generating reconstructions using the time-resolved projection data; and

computing the volumetric perfusion in the spatially dynamic object using the reconstructed data.

2. The method of claim 1, comprising temporally filtering the time-resolved data at the requisite view angle positions to generate filtered projection data.

3. The method of claim 2, wherein the step of processing and the step of temporally filtering are performed simultaneously.

4. The method of claim 1, wherein the spatially dynamic object comprises an organ.

5. The method of claim 1, comprising measuring an uptake and washout of a contrast enhancing medium in the spatially dynamic object as captured by the projection data acquired at requisite view angle positions of the gantry.

6. The method of claim 1, comprising identifying projection data at requisite view angle positions of the gantry corresponding to a predetermined temporal window of cyclic motion of the spatially dynamic object.

7. The method of claim 6, further comprising resampling the projection data by performing a fan-to-parallel rebinning process.

8. The method of claim 1, comprising acquiring the projection data in response to an external trigger.

9. The method of claim 8, wherein the external trigger comprises an electrocardiogram signal.

10. A computed tomography imaging system for computing volumetric perfusion in a spatially dynamic object, the system comprising:

a radiation source;

an area detector; and

a computer operationally coupled to the radiation source and the area detector, wherein the computer is configured to;

irradiate a spatially dynamic object within a field of view of the computed tomography imaging system for requisite view angles;

operate the computed tomography imaging system in a continuous data acquisition mode to acquire projection data representative of the spatially dynamic object;

process the projection data to generate time-resolved projection data;

generate reconstructions using the time-resolved projection data; and

compute the volumetric perfusion in the spatially dynamic object using the reconstructed data.

11. The computed tomography imaging system of claim 10, wherein the computer is configured to temporally filter the time-resolved data at the requisite view angle positions to generate filtered projection data.

12. The computed tomography imaging system of claim 11, wherein the computer is configured to simultaneously perform the step of processing and the step of temporally filtering.

13. The computed tomography imaging system of claim 10, wherein the computer is configured to acquire the projection data in response to an external trigger.

14. The computed tomography imaging system of claim 10, wherein the computer is configured to measure an uptake and washout of a contrast enhancing medium introduced into the spatially dynamic object as captured by the projection data measured at the requisite view angle positions of the gantry.

15. The computed tomography imaging system of claim 10, wherein the computer is configured to identify projection data at the requisite view angle positions corresponding to a predetermined temporal window of cyclic motion of the spatially dynamic object.

16. The computed tomography imaging system of claim 10, wherein the computer is configured to perform a fan-to-parallel rebinning process to resample the projection data.

17. A computer readable medium, comprising:

code adapted to irradiate a spatially dynamic object within a field of view of the computed tomography imaging system for requisite view angle positions of the gantry;

code adapted to operate the computed tomography imaging system in a continuous data acquisition mode to acquire projection data representative of the spatially dynamic object;

code adapted to process the projection data to generate time-resolved projection data;

code adapted to generate reconstructions using the time-resolved projection data; and

code adapted to compute the volumetric perfusion in the spatially dynamic object using the reconstructed data.

18. The computer readable medium of claim 17, comprising code adapted to temporally filter the time-resolved data at the requisite view angle positions to generate filtered projection data.

19. A method for computing volumetric perfusion using a computed tomography imaging system, the method comprising:

irradiating a spatially dynamic object within a field of view of the computed tomography imaging system for requisite view angle positions of the gantry;

operating the computed tomography imaging system in a continuous data acquisition mode to acquire projection data representative of the spatially dynamic object;

identifying projection data corresponding to a predetermined temporal window of cyclic motion of the spatially dynamic object;

performing a fan-to-parallel rebinning of the identified projection data to generate resampled projection data;

processing the resampled projection data to generate time-resolved projection data;

generating reconstructions using the time-resolved projection data; and

computing the volumetric perfusion in the spatially dynamic object using the reconstructed data.

20. The method of claim 19, comprising temporally filtering the time-resolved projection data at the requisite view angle positions to create filtered projection data.

21. The method of claim 19, comprising measuring an uptake and washout of a contrast enhancing medium in the spatially dynamic object as captured by the projection data measured at the requisite view angle positions of the gantry.

22. A method for computing volumetric perfusion using a computed tomography imaging system, the method comprising:

irradiating a spatially dynamic object within a field of view of the computed tomography imaging system for requisite view angle positions of the gantry;

operating the computed tomography imaging system in a continuous data mode to acquire projection data representative of the spatially dynamic object responsive to an external trigger;

processing the projection data to generate time-resolved projection data;

generating reconstructions using the time-resolved projection data; and

computing the volumetric perfusion in the spatially dynamic object using the reconstructed data.

23. The method of claim 22, comprising temporally filtering the time-resolved projection data at the requisite view angle positions of the gantry to create filtered projection data.

24. The method of claim 22, comprising performing a fan-to-parallel rebinning to resample the projection data prior to the step of processing the projection data to generate time-resolved projection data.