Automated oligomer synthesis
First Claim
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1. A system for automated oligomer synthesis, comprising:
- a synthesis station including a dispenser configured to dispense reagents for oligomer synthesis to reaction vessels, the synthesis station having an entrance and an exit;
a conveyor device including a plurality of receivers configured to hold the reaction vessels, the conveyor device being configured to drive the receivers through a closed loop that passes through the synthesis station; and
a controller configured to operate the synthesis station and the conveyor device so that oligomers are synthesized automatically as reaction vessels held by the receivers pass through the synthesis station from the entrance to the exit.
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Abstract
Systems, including apparatus and methods, for automated synthesis of oligomers.
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Citations
21 Claims
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1. A system for automated oligomer synthesis, comprising:
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a synthesis station including a dispenser configured to dispense reagents for oligomer synthesis to reaction vessels, the synthesis station having an entrance and an exit;
a conveyor device including a plurality of receivers configured to hold the reaction vessels, the conveyor device being configured to drive the receivers through a closed loop that passes through the synthesis station; and
a controller configured to operate the synthesis station and the conveyor device so that oligomers are synthesized automatically as reaction vessels held by the receivers pass through the synthesis station from the entrance to the exit. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A system for automated oligomer synthesis, comprising:
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a synthesis station including a dispenser configured to dispense reagents for oligomer synthesis to columns, the synthesis station having an entrance and an exit;
a conveyor device including a plurality of re-usable holders configured to support the columns, the conveyor device being configured to drive the holders through a closed loop that passes through the synthesis station; and
a controller configured to receive data defining sequences of subunits of oligomers to be synthesized and to operate the synthesis station and the conveyor device so that the oligomers are synthesized automatically as reaction columns disposed in the holders pass through the synthesis station from the entrance to the exit.
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15. A method of automated oligomer synthesis, comprising:
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driving a plurality of receivers in a closed loop that passes through a synthesis station including a dispenser configured to dispense reagents for oligomer synthesis to reaction vessels held by the receivers; and
operating the synthesis station and the conveyor device so that the oligomers are synthesized automatically as the reaction vessels pass through the synthesis station. - View Dependent Claims (16, 17, 18, 19, 20, 21)
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Specification