Metallic bone implant having improved implantability and method of making the same

• US 20050171615A1
• Filed: 01/31/2005
• Published: 08/04/2005
• Est. Priority Date: 01/30/2004
• Status: Active Grant

• Current Assignee: Frederick S. Georgette, Lee Allen Stouse
• Original Assignee: Frederick S. Georgette, Lee Allen Stouse
• Inventors: Georgette, Frederick S., Stouse, Lee Allen
• Granted Patent: US 7,981,461 B2
• Time in Patent Office: Days
• US Class Current: 623/23.500
• CPC Class Codes: A61C 8/0006 Periodontal tissue or bone regeneration support means for endoprosthetic bone substitute or bone graft implants A61F2/2846
• CPC Class Codes: A61C 8/0012 characterised by the material or composition, e.g. ceramics, surface layer, metal alloy use of specific materials A61K6/00
• CPC Class Codes: A61C 8/0013 with a surface layer, coating
• CPC Class Codes: A61F 2/30767 Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
• CPC Class Codes: A61F 2/30771 applied in original prostheses, e.g. holes or grooves
• CPC Class Codes: A61F 2/32 for the hip
• CPC Class Codes: A61F 2/38 for elbows or knees
• CPC Class Codes: A61F 2/44 for the spine, e.g. vertebrae, spinal discs
• CPC Class Codes: A61F 2002/30838 Microstructures
• CPC Class Codes: A61F 2002/30906 shot- sand- or grit-blasted
• CPC Class Codes: A61F 2310/00017 Iron- or Fe-based alloys, e.g. stainless steel
• CPC Class Codes: A61F 2310/00023 Titanium or titanium-based alloys, e.g. Ti-Ni alloys
• CPC Class Codes: A61F 2310/00029 Cobalt-based alloys, e.g. Co-Cr alloys or Vitallium
• CPC Class Codes: A61F 2310/00089 Zirconium or Zr-based alloys
• CPC Class Codes: A61F 2310/00095 Niobium or Nb-based alloys
• CPC Class Codes: A61F 2310/00131 Tantalum or Ta-based alloys
• CPC Class Codes: A61F 2310/00203 containing alumina or aluminium oxide
• CPC Class Codes: A61F 2310/00239 containing zirconia or zirconium oxide ZrO2
• CPC Class Codes: A61L 27/04 Metals or alloys
• CPC Class Codes: A61L 27/306 Other specific inorganic materials not covered by A61L27/303 - A61L27/32
• CPC Class Codes: A61L 27/56 : Porous materials, e.g. foams or sponges

Abstract

An implantable device composed of a biocompatible material having an enhanced surface topography that has an implanted calcium ion concentration and method of making the same.

Claims

1. An implantable device comprising a biocompatible material having an enhanced surface topography wherein the biocompatible material has an implanted calcium ion concentration sufficient to enhance viability of bone cells in contact with the enhanced surface topography.

2. The implantable device of claim 1 wherein the calcium ion concentration is present in the biocompatible material at the surface to a depth of between 100 and 2500 angstroms.

3. The implantable device of claim 2 wherein the enhanced surface topography of the biocompatible material is a microscopically textured surface.

4. The implantable device of claim 2 wherein the enhanced surface topography of the biocompatible material is a macroscopically textured surface.

5. The implantable device of claim 4 wherein the macroscopically textured surface is a porous coating having an average pore size between 50 and 1000 microns.

6. The implantable device of claim 3 through 5 wherein the macroscopically roughened surface is essentially free of calcium phosphate.

7. The implantable device of claim 1 wherein the enhanced surface topography is at least one of a metal, a metal alloy, a ceramic, a natural or synthetic polymer, and composite of any of these materials.

8. The implantable device of claim 1 wherein the biocompatible material is at least one of titanium, niobium, zirconium, tantalum, cobalt, alloys thereof, and stainless steel.

9. An implant comprising:

a biocompatible material having an enhanced surface topography;

the biocompatible material having an implanted calcium ion concentration present from the surface to a depth of between 100 and 2500 angstroms.

10. The implant of claim 9 wherein the biocompatible material is at least one of titanium, niobium, zirconium, tantalum, cobalt, alloys thereof, and stainless steel.

11. The implant of claim 9 wherein the enhanced surface topography is at least one of a metal, a metal alloy, a ceramic, a natural or synthetic polymer, and composites of any of these materials.

12. A method for producing metallic bone implants, the method comprising the ordered steps of providing a metallic bone implant with an enhanced surface topography, and thereafter implanting calcium ions on the enhanced surface of the metallic bone implant material.

13. The method of claim 12, wherein the step of providing the metallic bone implant with an enhanced surface area comprises providing a porous metallic surface coating on the bone implant.

14. The method of claim 12, wherein the step of providing the metallic bone implant with an enhanced surface area comprises subjecting the bone implant to a surface roughening treatment.

15. The method of claim 14, wherein the surface roughening step comprises blasting the metallic bone implant with a blast media characterized by its solubility in strong acid, and further comprising the step of dissolving substantially all of the blast media remaining on the roughened surface of the bone implant using a solution comprising nitric acid.

16. The method of claim 15, wherein the roughened surface of the bone implant is characterized by surface roughness between 0.5 and 4.0 microns (Ra).