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Recombination systems and methods for eliminating nucleic acid sequences from the genome of eukaryotic organisms

  • US 20050172365A1
  • Filed: 01/05/2004
  • Published: 08/04/2005
  • Est. Priority Date: 07/04/2001
  • Status: Active Grant
First Claim
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1. A recombination system comprising:

  • a transgenic recombination construct capable of being inserted into the chromosomal DNA of a eukaryotic organism said construct comprising in a 5′

    - to 3′

    -orientation;

    a first homology sequence A and at least one recognition sequence for site-directed induction of DNA double-strand breaks; and

    a second homology sequence B, wherein the homology sequences A and B have a sufficient length and a sufficient homology that allows for homologous recombination; and

    an enzyme suitable for inducing DNA double-strand breaks at a recognition sequence for the site-directed induction of DNA double-strand breaks or a nucleic acid sequence encoding said enzyme.

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