Membrane suitable for use in an analyte sensor, analyte sensor, and associated method
First Claim
1. A membrane for use in an analyte sensor, comprising:
- at least one polymer; and
at least one superoxide-dismutase/catalase catalyst.
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Accused Products
Abstract
A multifunctional membrane is provided. The multifunctional membrane is suitable for use in an analyte sensor. In a particular application, the multifunctional membrane may be used in connection with an amperometric biosensor, such as a transcutaneous amperometric biosensor. Some functions of the membrane are associated with properties of membrane itself, which is comprised of crosslinked polymers containing heterocyclic nitrogen groups. For example, the membrane, by virtue of its polymeric composition, may regulate the flux of an analyte to a sensor. Such regulation generally improves the kinetic performance of the sensor over a broad range of analyte concentration. Other functions of the membrane are associated with functional components, such as a superoxide-dismutating/catalase catalyst, either in the form of an enzyme or an enzyme mimic, that can be bound to the scaffold provided by the membrane. The effect of any such enzyme or enzyme mimic is to lower the concentration of a metabolite, such as superoxide and/or hydrogen peroxide, in the immediate vicinity of the sensing layer of the biosensor. Lowering the concentrations of such metabolites, which are generally deleterious to the function of the sensor, generally protects or enhances biosensor integrity and performance. The membrane is thus an important tool for use in connection with analyte sensors, amperometric sensors, biosensors, and particularly, transcutaneous biosensors. A membrane-covered sensor and a method for making same are also provided.
701 Citations
55 Claims
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1. A membrane for use in an analyte sensor, comprising:
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at least one polymer; and
at least one superoxide-dismutase/catalase catalyst. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. An analyte sensor, comprising:
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a working electrode comprising a conductive material and a sensing layer in contact with the conductive material;
a membrane disposed on the sensing layer, the membrane comprising;
at least one polymer; and
a superoxide-dismutase/catalase catalyst; and
a counter electrode in operable communication with the working electrode.
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- 24. An analyte sensor, comprising an analyte-flux-reducing membrane and a superoxide-dismutatse/catalase catalyst incorporated into the membrane.
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38. An analyte sensor, comprising:
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a working electrode comprising a conductive material and a sensing layer in contact with the conductive material;
a counter electrode in operable communication with the working electrode; and
a superoxide-dismutase/catalase catalyst disposed in a locale of the sensing layer in an amount sufficient to reduce a concentration of at least one of superoxide and hydrogen peroxide within the locale of the sensing layer. - View Dependent Claims (39)
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40. An analyte sensor, comprising:
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a working electrode comprising a conductive material and a sensing layer in contact with the conductive material;
a counter electrode in operable communication with the working electrode; and
a catalyst disposed in a locale of the sensing layer in an amount sufficient to reduce a concentration of at least one metabolite within the locale of the sensing layer, the catalyst selected from a group consisting of a proteinaceous catalyst, a non-proteinaceous catalyst comprising a metallic component and an organic component wherein a metal atom of the metallic component and a nonmetallic ligand of the organic component form a union, and any combination thereof. - View Dependent Claims (41)
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42. A method for making an analyte sensor, comprising:
applying a solution to an analyte sensor, the solution comprising at least one polymer and at least one superoxide-dismutase/catalase catalyst. - View Dependent Claims (43)
- 44. A method comprising providing a superoxide-dismutase/catalase catalyst in a locale of a sensing layer of an analyte sensor.
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49. An analyte sensor, comprising:
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a working electrode comprising a conductive material and a sensing layer in contact with the conductive material;
a counter electrode in operable communication with the working electrode; and
a superoxide-dismutase/catalase catalyst disposed in a locale of the sensing layer in an amount sufficient to reduce neutraphil recruitment within the locale of the sensing layer. - View Dependent Claims (50)
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51. An analyte sensor, comprising:
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a working electrode comprising a conductive material and a sensing layer in contact with the conductive material;
a counter electrode in operable communication with the working electrode; and
a catalyst disposed in a locale of the sensing layer in an amount sufficient to reduce neutraphil recruitment within the locale of the sensing layer, the catalyst selected from a group consisting of a proteinaceous catalyst, a non-proteinaceous catalyst comprising a metallic component and an organic component wherein a metal atom of the metallic component and a nonmetallic ligand of the organic component form a union, and any combination thereof. - View Dependent Claims (52)
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53. A method for making an analyte sensor, comprising:
applying a solution to an analyte sensor, the solution comprising at least one polymer and at least one catalyst, the catalyst in an amount sufficient to reduce neutraphil recruitment in a locale of the sensor when the sensor operates at least partially in a living body. - View Dependent Claims (54, 55)
Specification