Method of lowering Glycaemic Index of foods

• US 20050175674A1
• Filed: 01/25/2005
• Published: 08/11/2005
• Est. Priority Date: 08/07/2002
• Status: Active Grant

• Current Assignee: BASF SE
• Original Assignee: Queen Bioactives Pty Ltd.
• Inventors: Lang, Timothy Ralston, O'Shea, Michael Gerard
• Granted Patent: US 8,129,350 B2
• Time in Patent Office: Days
• US Class Current: 424/442
• CPC Class Codes: A23L 33/10 using additives addition of substantially indigestible substances A23L33/21
• CPC Class Codes: A23L 33/105 Plant extracts, their artificial duplicates or their derivatives
• CPC Class Codes: A23L 33/11 Plant sterols or derivatives thereof, e.g. phytosterols
• CPC Class Codes: A23L 33/20 Reducing nutritive value; Dietetic products with reduced nutritive value
• CPC Class Codes: A23L 33/30 Dietetic or nutritional methods, e.g. for losing weight A23L33/10 takes precedence
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A61K 31/353 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047
• CPC Class Codes: A61K 31/7048 having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin , digitoxin or digoxin
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics

Abstract

A method of delaying digestion by an animal or a human of carbohydrates in food, comprising administering an effective amount of one or more flavonoids to the animal or human in conjunction with the food, wherein the flavonoids are selected from luteolin, apigenin, tricin and their pharmaceutically acceptable analogues and derivatives

Claims

1. A method of delaying digestion by an animal or a human of carbohydrates in food, comprising administering an effective amount of one or more flavonoids to the animal or human in conjunction with the food, wherein the flavonoids are selected from luteolin, apigenin, tricin and their pharmaceutically acceptable analogues and derivatives.

2. A method according to claim 1 wherein the amount of flavonoids administered is at least 7 mg per 50.0 g of carbohydrates in the food.

3. A method according to claim 1 wherein the flavonoids are derived from sugar cane.

4. A method according to claim 1 wherein the flavonoids include tricin and its analogues and derivatives.

5. A method according to claim 4 wherein the flavonoid is tricin or a tricin analogue or derivative.

6. A method according to claim 1 wherein the flavonoids are administered prior to the food.

7. A method according to claim 1 wherein the flavonoids are administered with the food.

8. A method according to claim 1 wherein the flavonoids are administered after the food.

9. A method according to claim 7 wherein the flavonoids are incorporated into the food.

10. A method according to claim 1 wherein the flavonoids are administered in conjunction with a nutritional fibre supplement.

11. A pharmaceutical formulation suitable for oral administration comprising an effective amount of one or more flavonoids selected from luteolin, apigenin, tricin and their pharmaceutically acceptable analogues and derivatives and one or more pharmaceutically acceptable excipients.

12. A formulation according to claim 11 wherein the flavonoids are derived from sugarcane.

13. A formulation according to claim 11 or wherein the flavonoids include tricin and its pharmaceutically acceptable analogues and derivatives.

14. A formulation according to claim 13 wherein the flavonoid is tricin or a pharmaceutically acceptable tricin analogue or derivative.

15. A formulation according to any claim 11 wherein the formulation includes a nutritional fibre supplement.

16. A method of producing an oral pharmaceutical formulation for inhibiting intestinal enzymes, comprising combining one or more flavonoids selected from luteolin, apigenin, tricin and their pharmaceutically acceptable analogues and derivatives with one or more pharmaceutically acceptable excipients.

17. A method according to claim 16 wherein the flavonoids are derived from sugar cane.

18. A method according to claim 16 wherein the flavonoids include tricin or its pharmaceutically acceptable analogues and derivatives.

19. A method according to claim 18 wherein the flavonoid is tricin or a pharmaceutically acceptable tricin analogue or derivative.

20. A method according to claim 16 wherein the formulation also includes a nutritional fibre supplement.

21. A food product containing carbohydrates which also contains sufficient added flavonoids selected from luteolin, apigenin, tricin and their nutritionally acceptable analogues and derivatives to reduce the glycaemic index of the food product.

22. A food product according to claim 21 wherein the amount of added flavonoids contained in the food product is at least 7 mg per 50.0 g of carbohydrate in the food.

23. A food product according to claim 21 wherein the food product also contains a nutritional fibre supplement.

24. A food product according to claim 21 wherein the flavonoids are derived from sugar cane.

25. A food product according to claim 21 wherein the flavonoids include tricin or its analogues and derivatives.

26. A food product according to claim 25 wherein the flavonoid is tricin or a tricin analogue or derivative.

27. A method of lowering the glycaemic index of a carbohydrate-containing meal comprising including as part of the meal an effective amount of an extract of sugar cane containing tricin or its nutritionally acceptable analogues and derivatives.

28. A method according to claim 27 wherein the extract contains at least 5% tricin diglycoside.

29. A method according to claim 27 wherein the extract is obtained by:

a. mixing one part dunder with two parts 96% ethanol and allowing to settle for 24 hours;

b. filtering the dunder/ethanol mixture at 0.1 micron to obtain a permeate;

c. concentrating the permeate by evaporation to approximately 15% of its initial volume, and refiltering the concentrate;

d. adding approximately 0.1% by volume acetic acid to the filtered concentrate and passing the resulting mixture through a chromatography column loaded with XAD resin;

e. washing the chromatography column with one bed volume water containing 0.1% v/v acetic acid, followed by successive elution with 20%, 30% and 40% v/v ethanol in water solutions containing 0.1% v/v acetic acid; and

f. collecting the 40% fraction and evaporating to dryness at low temperature to obtain a sugar cane extract containing about 5% tricin diglycoside.

30. A method according to claim 27 wherein the amount of extract ranges from 0.3 g to 2.0 g per 50.0 g of carbohydrate in the meal.

31. A method according to claim 30 wherein the amount of extract is about 1.0 g per 50.0 g of carbohydrate in the meal.

32. A method according to claim 27 wherein the extract is added to the meal during preparation of the meal.

33. A method of lowering the glycaemic index of a carbohydrate-containing meal which comprises including as part of the meal an effective amount of tricin or its nutritionally acceptable analogues or derivatives.

34. A method according to claim 33 wherein the amount of tricin or tricin analogue or derivative is at least 7 mg per 50.0 g of carbohydrate in the meal.

35. A method according to claim 33 wherein the amount of tricin or tricin analogue or derivative ranges from 15 mg to 100 mg per 50.0 g of carbohydrate in the meal.

36. A method according to claim 35 wherein the amount of tricin or tricin analogues or derivatives is about 50 mg per 50.0 g of carbohydrate in the meal.

37. A method according to claim 33 wherein the tricin or tricin analogues or derivatives are added to the meal during preparation of the meal.