Polyethyleneglycol-modified lipid compounds and uses thereof
First Claim
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1. A compound of Formula I having the following structure:
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Abstract
The present invention provides compositions comprising polytheylyene-dialkyloxypropyl conjugates (PEG-DAA), liposomes, SNALP, and SPLP comprising such compositions, and methods of using such compositions, liposomes, SNALP, and SPLP.
61 Citations
62 Claims
- 1. A compound of Formula I having the following structure:
- 18. A liposome, said liposome comprising a polyethyleneglycol-dialkyloxypropyl (PEG-DAA) conjugate of Formula I having the following structure:
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25. A nucleic acid-lipid particle comprising:
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a nucleic acid;
a cationic lipid;
a non-cationic lipid; and
a polyethyleneglycol-dialkyloxypropyl (PEG-DAA) conjugate of Formula I having the following structure;
wherein;
R1 and R2 are independently selected and are alkyl groups having from about 10 to about 20 carbon atoms;
PEG is a polyethyleneglycol; and
L is a non-ester containing linker moiety. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61)
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62. A method of introducing a nucleic acid into a cell, said method comprising contacting said cell with a nucleic acid-lipid particle comprising a cationic lipid, a non-cationic lipid, a PEG-DAA conjugate, and a nucleic acid.
Specification