Capillary moderator for osmotic delivery system

• US 20050175701A1
• Filed: 02/07/2005
• Published: 08/11/2005
• Est. Priority Date: 02/10/2004
• Status: Abandoned Application

• Current Assignee: Intarcia Therapeutics, Inc.
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Goldman, Eli Joseph, Pan, Li-Wei, Panos, Rodney M.
• Application Number:
  US11/052,382
• Publication Number:
  US 20050175701A1
• Time in Patent Office: Days
• US Class Current: 424/473
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61M 2005/14513 with secondary fluid driving or regulating the infusion

Abstract

The present invention relates to apparatus and methods for preventing backflow into a beneficial agent dispensing osmotic delivery system.

Claims

1. An osmotic delivery system for dispensing a beneficial agent, comprising:

a housing having an inlet and an outlet;

a beneficial agent reservoir disposed in the housing; and

a capillary moderator disposed in the outlet for preventing backflow into the beneficial agent reservoir.

2. The system of claim 1, further comprising an osmotic pump adapted to cause the controlled release of the beneficial agent.

3. The system of claim 1, wherein the capillary moderator has a plurality of micro channels disposed between the environment and the beneficial agent reservoir.

4. The system of claim 3, wherein the micro channels prevent fluids from flowing from the environment to the beneficial agent reservoir.

5. The system of claim 3, wherein the micro channels have a diameter in a range from about 10 μ

m to about 100 μ

m.

6. The system of claim 3, wherein the micro channels have a diameter in a range from about 15 μ

m to about 50 μ

m.

7. The system of claim 3, wherein the micro channels have a diameter selected from about 15 μ

m, about 30 μ

m, and about 50 μ

m.

8. The system of claim 3, wherein the micro channels have a length in a range from about 150 μ

m to about 400 μ

m.

9. The system of claim 3, wherein the micro channels have a length of about 300 μ

m.

10. The system of claim 3, wherein the micro channels are crenulated.

11. The system of claim 3, wherein the micro channels are coated with a hydrophobic polymer.

12. The system of claim 3, wherein the micro channels are coated with a hydrophobic fluropolymer.

13. The system of claim 11, wherein the polymer is selected from at least one of Poly(1,1-dihydro-perfluorooctyl methacrylate), Poly(hexafluoropropylene), Poly(tetrafluoroethylene), Poly(vinylidene fluoride), Poly(1,2-butadiene), Polyisobutylene, Poly(vinyl fluoride), Poly(vinyl methyl ether), Polypropylene), Poly(t-butylstyrene), Halogenated Hydrocarbons, including Poly(hexafluoroethylene) and Poly(tetrafluoroethylene), Vinyl Polymers, including Poly((heptafluoroisopropoxy)ethylene), Nonfluorinated Acrylic Polymers, including Poly(ethyl acrylate), Fluorinated Acrylic Polymers, including Poly((1-chlorodifluoromethyl)tetrafluoroethyl acrylate)), Poly(di(chlorodifluoromethyl)fluoromethyl acrylate), Poly(1,1-dihydroheprafluorobutyl acrylate), Poly(1,1-dihydropentafluoroisoprpyl acrylate), Poly(1,1-dihydropentadecafluorooctyl acrylate), Poly(heptafluoroisopropyl acrylate), Poly(5-(heptafluoroisopropoxy)pentyl acrylate), Poly(11-(heptafluoroisopropoxy)ethyl acrylate), Poly(2-heptafluoropropoxy)ethyl acrylate, and Poly(nonafluoroisobutyl acrylate), Nonfluorinated Methacrylic Polymers, including Poly(isobutyl methacrylate) and Poly(t-butyl methacrylate), Fluorinated Methacrylic Polymers, including Poly(1,1-dihydropentadecafluorooctyl methacrylate), Poly(heptadecafluorooctyl methacrylate), Poly(heptafluoroisopropyl methacrylate), Poly(1-hydrotetrafluoroethyl methacrylate), Poly(1,1-dihydrotetrafluoropropyl methacrylate), Poly(1-hydrohexafluoroisopropyl methacrylate), Poly(t-nonafluorobutyl methacrylate), Polyethers, including Poly(oxyisobutene)-diol, Poly(imines), including Poly((benzoylimino)ethylene), Poly((butylrylimino)ethylene), Poly(dodecanoylimino)ethylene), Poly((heptanoylimino)ethylene), Poly((hexanoylimino)ethylene), Poly(((3-methyl)butyrylimino)ethylene), Poly((pentadecafluorooctadecanoylimino)ethylene), and Poly((pentanoylimino)ethylene), and Poly(siloxanes), including Poly(oxydiethylsilylene) and Poly(oxydimethylsilylene).

14. The system of claim 12, wherein the thickness of the coating in the micro channels varies in a range from about 0.50 μ

m to about 2 μ

m.

15. The system of claim 12, wherein the thickness of the coating in the micro channels is about 1 μ

m.

16. A method for preventing backflow into the beneficial agent reservoir of an osmotic delivery system, comprising:

providing a capillary moderator between the environment and the beneficial agent reservoir.

17. The method of claim 16, wherein the capillary moderator has a plurality of micro channels extending therethrough.

18. The method of claim 17, wherein the micro channels are crenulated.

19. The method of claim 17, further comprising coating the micro channels with a hydrophobic polymer.

20. The method of claim 19, wherein the polymer is selected from at least one of Poly(1,1-dihydro-perfluorooctyl methacrylate), Poly(hexafluoropropylene), Poly(tetrafluoroethylene), Poly(vinylidene fluoride), Poly(1,2-butadiene), Polyisobutylene, Poly(vinyl fluoride), Poly(vinyl methyl ether), Polypropylene), Poly(t-butylstyrene), Halogenated Hydrocarbons, including Poly(hexafluoroethylene) and Poly(tetrafluoroethylene), Vinyl Polymers, including Poly((heptafluoroisopropoxy)ethylene), Nonfluorinated Acrylic Polymers, including Poly(ethyl acrylate), Fluorinated Acrylic Polymers, including Poly((1-chlorodifluoromethyl)tetrafluoroethyl acrylate)), Poly(di(chlorodifluoromethyl)fluoromethyl acrylate), Poly(1,1-dihydroheprafluorobutyl acrylate), Poly(1,1-dihydropentafluoroisoprpyl acrylate), Poly(1,1-dihydropentadecafluorooctyl acrylate), Poly(heptafluoroisopropyl acrylate), Poly(5-(heptafluoroisopropoxy)pentyl acrylate), Poly(11-(heptafluoroisopropoxy)ethyl acrylate), Poly(2-heptafluoropropoxy)ethyl acrylate, and Poly(nonafluoroisobutyl acrylate), Nonfluorinated Methacrylic Polymers, including Poly(isobutyl methacrylate) and Poly(t-butyl methacrylate), Fluorinated Methacrylic Polymers, including Poly(1,1-dihydropentadecafluorooctyl methacrylate), Poly(heptadecafluorooctyl methacrylate), Poly(heptafluoroisopropyl methacrylate), Poly(1-hydrotetrafluoroethyl methacrylate), Poly(1,1-dihydrotetrafluoropropyl methacrylate), Poly(1-hydrohexafluoroisopropyl methacrylate), Poly(t-nonafluorobutyl methacrylate), Polyethers, including Poly(oxyisobutene)-diol, Poly(imines), including Poly((benzoylimino)ethylene), Poly((butylrylimino)ethylene), Poly(dodecanoylimino)ethylene), Poly((heptanoylimino)ethylene), Poly((hexanoylimino)ethylene), Poly(((3-methyl)butyrylimino)ethylene), Poly((pentadecafluorooctadecanoylimino)ethylene), and Poly((pentanoylimino)ethylene), and Poly(siloxanes), including Poly(oxydiethylsilylene) and Poly(oxydimethylsilylene).