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Diagnostic markers of mood disorders and methods of use thereof

  • US 20050176057A1
  • Filed: 03/14/2005
  • Published: 08/11/2005
  • Est. Priority Date: 09/26/2003
  • Status: Abandoned Application
First Claim
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1. A method of determining a probability of response of a subject of known clinical history to a pharmaceutical agent for a mood disorder, the method comprising:

  • correlating (i) a mutational burden at one or more nucleotide positions in genes drawn from the group consisting essentially of ADRBK2, BNDF, GSK3B, GRK3, IMPA1, IMPA2, INPP1, MARCKS, NTRK2 and/or NR1I2 within a sample taken from the subject of known clinical history with (ii) a mutational burden at one or more corresponding nucleotide positions in a control sample having known clinical history and response outcomes to the pharmaceutical agent; and

    determining from the correlating the probability of response of the subject to the pharmaceutical agent.

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