Alternatively spliced isoform of CDC25A phosphatase and methods of use

• US 20050176125A1
• Filed: 12/22/2004
• Published: 08/11/2005
• Est. Priority Date: 12/23/2003
• Status: Abandoned Application

• Current Assignee: Rosetta Inpharmatics LLC (Merck & Co., Inc.)
• Original Assignee: Rosetta Inpharmatics LLC (Merck & Co., Inc.)
• Inventors: Tsinoremas, Nicholas F., Castle, John, Armour, Christopher, Garrett-Engele, Philip W., Raymond, Christopher K., Kan, Zhengyan
• Application Number:
  US11/022,042
• Publication Number:
  US 20050176125A1
• Time in Patent Office: Days
• US Class Current: 435/196
• CPC Class Codes: C07H 21/04 with deoxyribosyl as saccharide radical
• CPC Class Codes: C12N 9/16 acting on ester bonds (3.1)

Abstract

The present invention features nucleic acids and polypeptides encoding a novel splice variant isoform of cell division cycle 25A (Cdc25A) phosphatase. The polynucleotide sequence of Cdc25Asv1 is provided by SEQ ID NO:2. The amino acid sequence for Cdc25Asv1 is provided by SEQ ID NO:3. The present invention also provides methods for using Cdc25Asv1 polynucleotides and proteins to screen for compounds that bind to Cdc25Asv1.

Claims

1. A purified human nucleic acid molecule comprising SEQ ID NO:

2, or the complement thereof.

2. The purified nucleic acid molecule of claim 1, wherein said nucleic acid molecule comprises a region encoding SEQ ID NO:

3.

3. The purified nucleic acid molecule of claim 1, wherein said nucleotide sequence encodes a polypeptide consisting of SEQ ID NO:

3.

4. A purified polypeptide comprising SEQ ID NO:

3.

5. The polypeptide of claim 4, wherein said polypeptide consists of SEQ ID NO:

3.