AFINITY DOMAIN FOR ANALYTE SENSOR

• US 20050176136A1
• Filed: 11/16/2004
• Published: 08/11/2005
• Est. Priority Date: 11/19/2003
• Status: Abandoned Application

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Tapsak, Mark, Burd, John, Rhodes, Rathbun
• Application Number:
  US10/991,353
• Publication Number:
  US 20050176136A1
• Time in Patent Office: Days
• US Class Current: 435/287.200
• CPC Class Codes: A61B 17/3468 for implanting or removing devices, e.g. prostheses, implants, seeds, wires devices for implanting seeds A61M37/0069
• CPC Class Codes: A61B 2017/3492 against the outside of the body
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 2560/045 with a separable interface unit, e.g. for communication
• CPC Class Codes: A61B 2562/18 Shielding or protection of sensors from environmental influences, e.g. protection from mechanical damage
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/0004 characterised by the type of physiological signal transmitted
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/14 Devices for taking samples of blood hypodermic syringes A61M5/00; Measuring characteristics of blood in vivo, e.g. gas concentration within the blood, pH-value of blood measuring of blood pressure A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/1411 by percutaneous method, e.g. by lancet
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14503 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence
• CPC Class Codes: A61B 5/14507 specially adapted for measuring characteristics of body fluids other than blood devices for taking samples of body liquids A61B10/0045
• CPC Class Codes: A61B 5/14514 using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1468 using chemical or electrochemical methods, e.g. by polarographic means A61B5/1486 takes precedence
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/14735 comprising an immobilised reagent
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/14865 : invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/1495 : Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/150022 : for capillary blood or interstitial fluid
• CPC Class Codes: A61B 5/6801 : specially adapted to be attached to or worn on the body surface
• CPC Class Codes: A61B 5/6833 : Adhesive patches
• CPC Class Codes: A61B 5/68335 : including release sheets or liners
• CPC Class Codes: A61B 5/6848 : Needles
• CPC Class Codes: A61B 5/6849 : in combination with a needle set
• CPC Class Codes: A61B 5/72 : Signal processing specially adapted for physiological signals or for diagnostic purposes character recognition, recognising digital ink, document-oriented image-based pattern recognition G06V30/00; recognition or understanding of postal images G06V30/424
• CPC Class Codes: A61M 2005/1585 : Needle inserters
• CPC Class Codes: A61M 5/14244 : adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/1723 : using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: C12Q 1/002 : Electrode membranes
• CPC Class Codes: Y02A 90/10 : Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

Abstract of the Disclosure

The preferred embodiments provide a membrane system, particularly for use on an electrochemical sensor, wherein the membrane system includes an affinity domain that dampens the effects of target interferant(s) on the sensor. The affinity domain can be layer, surface, region, and/or portion of the membrane system formed using sorbents that have an affinity for the target interferant. The sorbents can be adapted to adsorb the interferants, for example using adsorbents such as chromatography packing materials. The sorbents can also be adapted to absorb the interferants by imprinting a molecular structure on the material that forms the affinity domain such that target interferants bind to the imprinted surfaces at the molecular level.

Claims

1. A membrane suitable for use with an analyte sensor, the membrane comprising an affinity domain, wherein the affinity domain comprises a sorbent having an affinity for an interfering species.

2. The membrane of claim 1, wherein the sorbent has an affinity for a phenol-containing species.

3. The membrane of claim 2, wherein the sorbent has an affinity for acetaminophen.

4. The membrane of claim 1, wherein the sorbent comprises an adsorbent substance.

5. The membrane of claim 4, wherein the adsorbent substance comprises a chromatography-packing material.

6. The membrane of claim 1, wherein the sorbent comprises a molecularly imprinted surface adapted to bind with the interfering species by covalent adherence.

7. The membrane of claim 1, wherein the sorbent comprises a molecular structure that has a geometric structure and hydrogen binding capability, wherein the molecular structure is adapted to bind with the interfering species.

8. An electrochemical sensor comprising the membrane of claim 1.

9. A wholly implantable glucose sensor comprising the membrane of claim 1.

10. A transcutaneous glucose sensor comprising the membrane of claim 1.

11. An analyte sensor for measuring the concentration of an analyte in a host, the sensor comprising:

12. The sensor of claim 11, wherein the sensing region comprises an electroactive surface and wherein the membrane system comprises an enzyme capable of reacting with the analyte.

13. The sensor of claim 11, wherein the affinity domain comprises a sorbent, wherein the sorbent is configured to slow the diffusion of the interfering species through the membrane system to the sensing region.

14. The sensor of claim 13, wherein the sorbent has an affinity for a phenol-containing species.

15. The sensor of claim 14, wherein the sorbent has an affinity for acetaminophen.

16. The sensor of claim 11, wherein the sensor is adapted for implantation in a soft tissue of the host.

17. The sensor of claim 16, wherein the sensor is adapted for whole implantation within the host.

18. The sensor of claim 16, wherein the sensor is adapted for transcutaneous implantation in the host.