Detector arrangement based on surfaces plasmon resonance
First Claim
1. A detector arrangement comprising a) a rotary member having an axis of rotation, said member comprises:
- (i) one or more microfluidic discs, each disc comprises a plurality of essentially equal and enclosed microchannel structures which are designed for permitting liquid transport by centrifugal force created by spinning the disc around the axis of rotation, and a first plurality of surface plasmon resonance measuring cells (SPR-MCs), each SPR-MCs comprises a detection microcavity (DMC), wherein an SPR surface in an inner wall of the DMC and at least a part (P1) of a detection window (DW) that stretches from the SPR surface to an outer surface of the disc, and said outer surface of P1 for all SPR-MCs are at the same radial distances (ii) a rotatable disc holder comprising the remaining part (P2) of each of the DWs, b) a non-rotatable SPR detector comprising (i) a light source (LS), and (ii) a light detecting subunit (LDS), c) a beam path comprising (i) an incident beam path (ibp) going from LS to one of the SPR surfaces via the DW associated with this SPR surface, and (ii) a reflected beam path (rpb) going from the same SPR surface to LDS via said DW, the SPR-MCs being interchangeable by rotating said rotatory member.
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Accused Products
Abstract
A detector arrangement, which comprises a rotatable microfluidic disc and a spectrophotometric detector unit. The arrangement is characterized in that the detector unit is based on surface plasmon resonanc (SPR) and is capable of measuring an analyte within the detection microcavities, each of which is part of a microchannel structure. A microfluidic disc having an axis of symmetry and comprising microchannel structures, each of which has an upstream functional part that is at a shorter radial position than a downstream functional part. The disc is characterized in that there are detection microcavities (DMCs) in at least a part of said microchannel structures, and that each of said DMCs has an SPR surface on an inner wall and a detection detection window extending from the SPR surface to the surface of the disc. The use of the detector arrangement and microfluidic disc described above for determining: a) if the content in one or more of the DMCs is a liquid or a solid state or a gas, and/or b) a feature of an analyte that may be present in a liquid which is present in one or more of the DMCs.
108 Citations
20 Claims
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1. A detector arrangement comprising
a) a rotary member having an axis of rotation, said member comprises: -
(i) one or more microfluidic discs, each disc comprises a plurality of essentially equal and enclosed microchannel structures which are designed for permitting liquid transport by centrifugal force created by spinning the disc around the axis of rotation, and a first plurality of surface plasmon resonance measuring cells (SPR-MCs), each SPR-MCs comprises a detection microcavity (DMC), wherein an SPR surface in an inner wall of the DMC and at least a part (P1) of a detection window (DW) that stretches from the SPR surface to an outer surface of the disc, and said outer surface of P1 for all SPR-MCs are at the same radial distances (ii) a rotatable disc holder comprising the remaining part (P2) of each of the DWs, b) a non-rotatable SPR detector comprising (i) a light source (LS), and (ii) a light detecting subunit (LDS), c) a beam path comprising (i) an incident beam path (ibp) going from LS to one of the SPR surfaces via the DW associated with this SPR surface, and (ii) a reflected beam path (rpb) going from the same SPR surface to LDS via said DW, the SPR-MCs being interchangeable by rotating said rotatory member. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. (canceled)
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20. A microfluidic disc having an axis of symmetry and comprising a plurality of microchannel structures, each of which has an upstream functional part that at least partly is at a shorter radial position than a downstream functional part and in fluid communication with said downstream functional part, said disc comprises detection microcavities (DMCs) in at least a part of said microchannel structures, and each of said DMCs has an SPR surface on an inner wall and a detection window extending from the SPR surface to the surface of the disc, which detection window is translucent for light giving surface plasmon resonance.
Specification