Systems for using sample processing devices

• US 20050180890A1
• Filed: 03/16/2005
• Published: 08/18/2005
• Est. Priority Date: 12/28/2001
• Status: Active Grant

• Current Assignee: Diasorin Italia SPA
• Original Assignee: 3M Innovative Properties Company (3M Company)
• Inventors: Aysta, James E., Bedingham, William, Robole, Barry W.
• Granted Patent: US 7,569,186 B2
• Time in Patent Office: Days
• US Class Current: 422/99
• CPC Class Codes: B01L 2300/0803 Disc shape
• CPC Class Codes: B01L 2300/1861 using radiation
• CPC Class Codes: B01L 3/50851 specially adapted for heating or cooling samples laboratory heating apparatus B01L7/00; incubators C12M
• CPC Class Codes: B01L 7/52 with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples amplification or hybridisation processes per se C12Q1/68; controlling sequential reactions for synthesis B01J19/0046
• CPC Class Codes: B01L 7/54 using spatial temperature gradients
• CPC Class Codes: B01L 9/523 for multisample carriers, e.g. used for microtitration plates
• CPC Class Codes: G01N 2035/00326 Analysers with modular structure
• CPC Class Codes: G01N 35/025 having a carousel or turntable for reaction cells or cuvettes
• CPC Class Codes: Y10T 436/111666 Utilizing a centrifuge or compartmented rotor

Abstract

Sample processing systems for processing sample materials located in sample processing devices that are separate from the system are disclosed. The sample processing systems include a rotating base plate with raised and/or non-planar thermal structures on which the sample processing devices are located during operation of the systems. The systems may also include structure to urge the sample processing devices against the base plate and thermal structures.

Claims

1. A sample processing system comprising:

a base plate adapted to receive a sample processing device proximate a top surface of the base plate;

a thermal structure exposed on the top surface of the base plate, wherein an upper surface of the thermal structure contacts a sample processing device received proximate the top surface of the base plate, and wherein the upper surface of the thermal structure is raised relative to the top surface of the base plate adjacent the thermal structure;

a drive system adapted to rotate the base plate about an axis of rotation; and

an electromagnetic energy source adapted to direct electromagnetic energy at the thermal structure while the base plate is rotating about the axis of rotation.

2. A system according to claim 1, wherein the thermal structure comprises shoulders that set the upper surface of the thermal structure off from the top surface of the base plate adjacent the thermal structure.

3. A system according to claim 1, wherein the thermal structure comprises at least one raised protrusion that extends above surrounding portions of the upper surface of the thermal structure.

4. A system according to claim 1, wherein the upper surface of the thermal structure comprises a non-planar surface.

5. A system according to claim 1, wherein the thermal structure raises a sample processing device such that the sample processing device does not contact the top surface of the base plate adjacent the thermal structure.

6. A system according to claim 1, wherein a plurality of the thermal structures are attached to the base plate.

7. A system according to claim 1, wherein the thermal structure comprises a continuous ring structure.

8. A system according to claim 1, wherein the thermal structure comprises a lower surface that is exposed proximate a bottom surface of the base plate.

9. A system according to claim 8, wherein the thermal structure is opaque to the electromagnetic energy emitted by the electromagnetic energy source.

10. A system according to claim 1, further comprising a platen adapted to force a sample processing device against the upper surface of the thermal structure.

11. A system according to claim 1, further comprising a spindle that extends through a central opening in a sample processing device, the spindle adapted to draw the sample processing device towards the top surface of the base plate.

12. A system according to claim 1, further comprising means for urging a sample processing device against the upper surface of the thermal structure.

13. A sample processing system comprising:

a base plate adapted to receive a sample processing device proximate a top surface of the base plate;

a thermal structure exposed on the top surface of the base plate, wherein an upper surface of the thermal structure contacts a sample processing device received proximate the top surface of the base plate, and wherein the upper surface of the thermal structure is raised relative to the top surface of the base plate adjacent the thermal structure, and wherein the thermal structure comprises shoulders that set the upper surface of the thermal structure off from the top surface of the base plate adjacent the thermal structure, and wherein the thermal structure comprises at least one raised protrusion that extends above the surrounding portions of the upper surface of the thermal structure, and still further wherein the thermal structure comprises a lower surface that is exposed proximate a bottom surface of the base plate;

a drive system adapted to rotate the base plate about an axis of rotation; and

an electromagnetic energy source adapted to direct electromagnetic energy at the thermal structure while the base plate is rotating about the axis of rotation.

14. A sample processing system comprising:

a base plate adapted to receive a sample processing device proximate a top surface of the base plate;

a thermal structure exposed on the top surface of the base plate, wherein the thermal structure comprises a non-planar upper surface;

a drive system adapted to rotate the base plate about an axis of rotation; and

an electromagnetic energy source adapted to direct electromagnetic energy at the thermal structure while the base plate is rotating about the axis of rotation.

15. A system according to claim 14, wherein the thermal structure comprises shoulders that set the upper surface of the thermal structure off from the top surface of the base plate adjacent the thermal structure.

16. A system according to claim 14, wherein the non-planar upper surface of the thermal structure comprises a plurality of raised protrusions extending upward from surrounding portions of the upper surface.

17. A system according to claim 14, wherein the non-planar upper surface of the thermal structure raises a sample processing device received proximate the top surface of the base plate such that the sample processing device does not contact the top surface of the base plate adjacent the thermal structure.

18. A system according to claim 14, wherein a plurality of the thermal structures are attached to the base plate.

19. A system according to claim 14, wherein the thermal structure comprises a continuous ring structure.

20. A system according to claim 14, wherein the thermal structure comprises a lower surface that is exposed proximate a bottom surface of the base plate.

21. A system according to claim 20, wherein the thermal structure is opaque to the electromagnetic energy emitted by the electromagnetic energy source.

22. A system according to claim 14, further comprising a platen adapted to force a sample processing device against the upper surface of the thermal structure.

23. A system according to claim 14, further comprising a spindle that extends through a central opening in a sample processing device, the spindle adapted to draw the sample processing device towards the top surface of the base plate.

24. A system according to claim 14, further comprising means for urging a sample processing device against the upper surface of the thermal structure.

25. A sample processing system comprising:

a base plate adapted to receive a sample processing device proximate a top surface of the base plate;

a thermal structure exposed on the top surface of the base plate, wherein the thermal structure comprises an upper surface that contacts a sample processing device received proximate the top surface of the base plate;

means for urging a sample processing device towards the top surface of the base plate, wherein the sample processing device is forced against the upper surface of the thermal structure;

a drive system adapted to rotate the base plate about an axis of rotation;

an electromagnetic energy source adapted to direct electromagnetic energy at the thermal structure while the base plate is rotating about the axis of rotation.

26. A sample processing system comprising:

a base plate adapted to receive a sample processing device proximate a top surface of the base plate;

a thermal structure exposed on the top surface of the base plate, wherein the thermal structure comprises an upper surface that contacts a sample processing device received proximate the top surface of the base plate;

a drive system adapted to rotate the base plate about an axis of rotation;

a platen adapted to force a sample processing device against the upper surface of the thermal structure; and

an electromagnetic energy source adapted to direct electromagnetic energy at the thermal structure while the base plate is rotating about the axis of rotation.

27. A sample processing system comprising:

a base plate adapted to receive a sample processing device proximate a top surface of the base plate;

a thermal structure exposed on the top surface of the base plate, wherein the thermal structure comprises an upper surface that contacts a sample processing device received proximate the top surface of the base plate;

a drive system adapted to rotate the base plate about an axis of rotation;

a spindle that extends through a central opening in a sample processing device, the spindle adapted to draw the sample processing device towards the top surface of the base plate; and

an electromagnetic energy source adapted to direct electromagnetic energy at the thermal structure while the base plate is rotating about the axis of rotation.