Decullularized extracellular matrix of conditioned body tissues and uses thereof
First Claim
1. An apparatus, comprising:
- a medical device having a biodegradable material and a decellularized extracellular matrix, wherein the medical device is configured to be implanted into a human patient, the biodegradable material is formulated to degrade within the human patient, the decellularized extracellular matrix is formulated to be released as the biodegradable material degrades.
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Abstract
The invention is directed to an apparatus, such as a medical device, having a surface coated or covered with a decellularized extracellular matrix or having a component comprising the decellularized extracellular matrix for implantation into a subject, preferably a human. In one embodiment of the invention, a decellularized extracellular matrix is used to form a bodily implant such as a vein, an artery, an esophagus, or a ventricular restraining device. In some embodiments of the invention, the decellularized extracellular matrix is configured to be a time released therapeutic. In another embodiment of the invention, a decellularized extracellular matrix forms an aneurysm treatment device, such as an aneurysm coil, a seal, a pouch, or a filler. In a further embodiment of the invention, decellularized extracellular matrix is used to embolize lesions, tumors, or vessels. Methods for making the tissue regeneration scaffold and methods for manufacturing a coated or covered medical device having a component comprising decellularized extracellular matrix of body tissues are also provided.
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Citations
18 Claims
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1. An apparatus, comprising:
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a medical device having a biodegradable material and a decellularized extracellular matrix, wherein the medical device is configured to be implanted into a human patient, the biodegradable material is formulated to degrade within the human patient, the decellularized extracellular matrix is formulated to be released as the biodegradable material degrades. - View Dependent Claims (2, 3)
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4. An apparatus, comprising:
a compression molded medical device, the compression molded medical device including a decellularized extracellular matrix. - View Dependent Claims (5, 6, 7, 8)
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9. An apparatus, comprising:
a medical device defining a cavity, the medical device including a decellularized extracellular matrix, the cavity being configured to receive a heart of a patient. - View Dependent Claims (10)
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11. A method making a medical device, comprising:
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providing a decellularized extracellular matrix; and
forming a pouch that defines a cavity, the cavity being configured to receive a heart of a mammal.
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12. An apparatus, comprising:
a tubular member having a decellularized extracellular matrix layer and a elastomeric biocompatible polymer layer, the tubular member being configured to be implanted into a body of a mammal. - View Dependent Claims (13, 14, 15, 16, 17, 18)
Specification