Percutaneously placed prosthesis with thromboresistant valve portion
First Claim
1. A valve prosthesis for implantation in blood vessel, comprising:
- a support structure having a first configuration and a first diameter for delivery through a blood vessel and a second configuration and second diameter for implantation therein, the support structure including a passageway extending therethrough;
the support structure further comprising a valve portion having a first and second end and that includes a valve support housing and one or more valve-closing elements attached thereto and configured to permit blood flowing through the passageway in a first direction and restricting blood flow in a second direction opposite the first direction; and
an anchoring portion, the support structure further comprising an anchoring portion attached about the valve portion;
wherein the support structure is configured such that the valve portion is substantially non-self expanding when no longer constrained by the delivery system, while the anchoring portion expands to the second diameter valve portion to engage the walls of the blood vessel and anchors the prosthesis therein.
1 Assignment
0 Petitions
Accused Products
Abstract
A venous valve prosthesis having a substantially non-expandable, valve portion comprising a valve-closing mechanism, such as a pair of opposing leaflets; and an anchoring portion, such as one or more self-expanding frames or stents that are expandable to anchor the prosthesis at the implantation site. In one embodiment, the rigid valve portion includes a deposition of material such as pyrolitic carbon to reduce the thrombogenecity of the blood-contacting surfaces. The anchoring portions preferably include a covering, such as a tubular construct of synthetic or collagen-derived material (such as a bioremodelable ECM material), which attaches about the support structure such that blood flow is directed through the valve mechanism as it transitions from the larger diameter anchoring portion to the intermediate, smaller-diameter portion of the prosthesis. In another embodiment, the valve support housing and valve-closing elements are delivered in a collapsed, folded, and/or dissembled state sized for delivery, then manipulated in situ to the second expanded configured following deployment.
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Citations
20 Claims
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1. A valve prosthesis for implantation in blood vessel, comprising:
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a support structure having a first configuration and a first diameter for delivery through a blood vessel and a second configuration and second diameter for implantation therein, the support structure including a passageway extending therethrough;
the support structure further comprising a valve portion having a first and second end and that includes a valve support housing and one or more valve-closing elements attached thereto and configured to permit blood flowing through the passageway in a first direction and restricting blood flow in a second direction opposite the first direction; and
an anchoring portion, the support structure further comprising an anchoring portion attached about the valve portion;
wherein the support structure is configured such that the valve portion is substantially non-self expanding when no longer constrained by the delivery system, while the anchoring portion expands to the second diameter valve portion to engage the walls of the blood vessel and anchors the prosthesis therein. - View Dependent Claims (2, 3, 5, 6, 7, 8, 12, 13, 14, 15, 16)
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9. The valve prosthesis of
FIG. 1 , wherein the anchoring portion comprises a covering configured to direct the blood flow through the valve portion.
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17. A valve prosthesis for implantation in a blood vessel comprising:
a support structure having a valve portion attached thereto, wherein the valve portion includes a deposition of pyrolitic carbon on at least a portion of the adluminal surface of the valve mechanism in an effective amount for improving thromboresistance, the support structure further comprising a anchoring portion configured to anchor the valve prosthesis within the implantation site.
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18. A valve prosthesis for implantation in a blood vessel comprising:
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a valve mechanism having blood-contacting surfaces and a substantially fixed outer diameter comprising the first diameter, the first diameter being sized for insertion into an intravascular sheath for introduction within the blood vessel; and
one or more anchoring elements attached to the valve mechanism, the one or more anchoring elements configured to be expandable to a second diameter that is larger than the first diameter, the second diameter being sufficient for engaging the walls of the blood vessel such that valve prosthesis is anchorable therein. - View Dependent Claims (19, 20)
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Specification