Photostable sunscreen compositions and methods of stabilizing

• US 20050186159A1
• Filed: 03/29/2005
• Published: 08/25/2005
• Est. Priority Date: 12/14/2001
• Status: Active Grant

• Current Assignee: Avon Products Incorporated
• Original Assignee: Avon Products Incorporated
• Inventors: Gonzalez, Anthony D., Kalafsky, Robert E., Pechko, Andrew H.
• Granted Patent: US 7,186,404 B2
• Time in Patent Office: Days
• US Class Current: 424/59
• CPC Class Codes: A61K 2800/52 Stabilizers
• CPC Class Codes: A61K 8/35 Ketones, e.g. benzophenone
• CPC Class Codes: A61K 8/37 Esters of carboxylic acids
• CPC Class Codes: A61K 8/9789 Magnoliopsida [dicotyledons]
• CPC Class Codes: A61K 8/9794 Liliopsida [monocotyledons]
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

Abstract

There is provided a photostable and synergistically enhanced topical sunscreen composition. There is further provided a method of enhancing the photostability of a sunscreen active in a topical sunscreen composition. There is further still provided a method of synergistically enhancing the UV absorbance of a sunscreen active in a topical sunscreen composition. The preferred compositions and methods of the present invention use a dibenzoylmethane sunscreen active, a Kaempferia galanga extract, and a cosmetically acceptable vehicle.

Claims

1. A method of enhancing the photostability of a sunscreen active in a topical sunscreen composition, the method comprising:

introducing into the composition an amount of Kaempferia galanga extract sufficient to enhance the photostability of the sunscreen active, wherein the sunscreen active is present in an amount from about 0.05 wt % to about 50 wt %, based upon the total weight of the composition.

2. The method of claim 1, wherein the Kaempferia galanga extract is obtained from the part of a plant selected from the group consisting of bark, flower, leaf, root, and stem.

3. The method of claim 2, wherein the Kaempferia galanga extract is obtained from the root of the plant.

4. The method of claim 1, wherein the Kaempferia galanga extract has at least one active ingredient selected from the group consisting of borneol, camphene, carene, 3-Carene borneol, 1,8-cineole, cinnamic acid ethyl ester, ethyl p-methoxycinnamate, isoamyl p-methoxycinnamate, n-pentadecane, p-methoxycinnamic acid ethyl ester, p-methoxycinnamic acid methyl ester and p-methoxystyrene.

6. The method claim 1, wherein the Kaempferia galanga extract is a synthetic Kaempferia galanga extract.

13. The method of claim 1, wherein the sunscreen active is selected from the group consisting of dibenzoylmethane or a derivative thereof, oxybenzone, sulisobenzone, dioxybenzone, menthyl anthranilate, para aminobenzoic acid (PABA), octyl methoxycinnamate, DEA methoxycinnamate, octocrylene, drometrizole trisiloxane, octyl salicylate, homomenthyl salicylate, octyl dimethyl PABA, TEA salicylate, 4-methyl benzilidene camphor, octyl triazone, phenyl benzimidazole sulfonic acid, terephthalydiene dicamphor sulfonic acid, ethyl PABA, hydroxy methylphenyl benzotriazole, methylene bis-benzotriazoyltetramethylbutylphenol, bis-ethylhexyloxyphenol methoxyphenol triazine, titanium dioxide, zinc oxide, any derivatives of the foregoing or any combinations of the foregoing.

17. The method of claim 1, wherein the sunscreen active is dibenzoylmethane or a derivative thereof.

18. The method of claim 17, wherein the dibenzoylmethane derivative is butylmethoxydibenzoylmethane.

19. The method of claim 1, wherein the weight ratio of the Kaempferia galanga extract to the at least one sunscreen active is about 0.01:

3 to about 3;

0.01.

5. (canceled)

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22. A method of synergistically enhancing the UV absorbance of a topical sunscreen composition comprising a sunscreen active and a cosmetically acceptable vehicle, the method comprising:

introducing into the composition an amount of Kaempferia galanga extract sufficient to synergistically enhance UV absorption, wherein the sunscreen active is present in an amount from about 0.05 wt % to about 50 wt %, based upon the total weight of the composition.

23. The method of claim 22, wherein the Kaempferia galanga extract is obtained from a Kaempferia galanga plant part selected from the group consisting of bark, flower, leaf, root, and stem.

24. The method of claim 22, wherein the Kaempferia galanga extract is obtained from a root part of the Kaempferia galanga plant.

25. The method of claim 22, wherein the Kaempferia galanga extract has at least one active ingredient selected from the group consisting of borneol, camphene, carene, 3-Carene borneol, 1,8-cineole, cinnamic acid ethyl ester, ethyl p-methoxycinnamate, isoamyl p-methoxycinnamate, n-pentadecane, p-methoxycinnamic acid ethyl ester, p-methoxycinnamic acid methyl ester and p-methoxystyrene.

27. The method claim 22, wherein the Kaempferia galanga extract is a synthetic Kaempferia galanga extract.

28. The method of claim 27, wherein the synthetic Kaempferia galanga extract has a chemical composition with about 50 percent or more commonality to a natural Kaempferia galanga extract.

35. The method of claim 22, wherein the sunscreen active is dibenzoylmethane or a derivative thereof.

36. The method of claim 35, wherein the dibenzoylmethane is butylmethoxydibenzoylmethane.

37. The method of claim 22, wherein the weight ratio of Kaempferia galanga extract to the at least one sunscreen active is about 0.01 to 0.05:

1.

88. The method of claim 22, wherein the synthetic Kaempferia galanga extract has four or more active ingredients in common with a natural Kaempferia galanga extract.

89. The method of claim 22, wherein the synthetic Kaempferia galanga extract has substantially the same number of active ingredients as a natural Kaempferia galanga extract.

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34. The method of claim 22, wherein the sunscreen active is at least one of dibenzoylmethane or a derivative thereof, oxybenzone, sulisobenzone, dioxybenzone, menthyl anthranilate, para aminobenzoic acid (PABA), octyl methoxycinnamate, DEA methoxycinnamate, octocrylene, drometrizole trisiloxane, octyl salicylate, homomenthyl salicylate, octyl dimethyl PABA, TEA salicylate, 4-methyl benzilidene camphor, phenyl benzimidazole sulfonic acid, octyl triazone, terephthalydiene dicamphor sulfonic acid, ethyl PABA, hydroxy methylphenyl benzotriazole, methylene bis-benzotriazoyltetramethylbutylphenol, bis-ethylhexyloxyphenol methoxyphenol triazine, titanium dioxide, zinc oxide, any derivatives of the foregoing or any combinations of the foregoing.

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39. A topical sunscreen composition, comprising:

from about 0.05 wt % to about 50 wt % of a sunscreen active and

a Kaempferia galanga extract.

40. The composition of claim 39, wherein the Kaempferia galanga extract is obtained from a Kaempferia galanga plant part selected from the group consisting of bark, flower, leaf, root, and stem.

41. The composition of claim 40, wherein the Kaempferia galanga extract is the extract from the root of a Kaempferia galanga plant.

42. The composition of claim 39, wherein the sunscreen active comprises one or more dibenzoylmethane, oxybenzone, sulisobenzone, dioxybenzone, menthyl anthranilate, para aminobenzoic acid (PABA), octyl methoxycinnamate, DEA methoxycinnamate, octocrylene, drometrizole trisiloxane, octyl salicylate, homomenthyl salicylate, octyl dimethyl PABA, TEA salicylate, 4-methyl benzilidene camphor, octyl triazone, terephthalydiene dicamphor sulfonic acid, phenyl benzimidazole sulfonic acid, ethyl PABA, hydroxy methylphenyl benzotriazole, methylene bis-benzotriazoyltetramethylbutylphenol, bis-ethylhexyloxyphenol methoxyphenol triazine, titanium dioxide, zinc oxide, or any derivatives thereof.

45. The composition of claim 39, wherein the sunscreen active is dibenzoylmethane or a derivative thereof.

46. The composition of claim 39, wherein the sunscreen active is butylmethoxydibenzoylmethane.

47. The composition of claim 39, wherein the Kaempferia galanga extract is present in an amount sufficient to enhance the photostability of the sunscreen active.

51. The composition of claim 39, wherein the weight ratio of the Kaempferia galanga extract to the sunscreen active is from about 0.01:

3 to about 3;

0.01.

57. The composition of claim 39, further comprising a film former.

59. The composition of claim 57, wherein the film former is present in an amount about 0.5 wt % to about 5 wt % based on the total weight of the composition.

60. The composition of claim 39, further comprising an insect repellent selected from the group consisting of N,N diethyl-m-toluamide, ethyl butylacetylaminopropionate, hydroxyethyl isobutyl piperidine carboxylate, oil of citronella, soy bean oil, lemon grass oil, geranium/geraniol oil, neem oil, p-menthane-3,8-diol, and any combinations thereof.

61. The composition of claim 39, wherein the composition is in the form of an aerosol, balm, cream, gel, lotion, mousse, patch, pomade, pump spray, roll-on, solution, stick or towelette.

62. The composition of claim 39, wherein the sunscreen active is butylmethoxydibenzoylmethane, and the weight ratio of the Kaempferia galanga extract to butylmethoxydibenzoylmethane is about 0.01:

3 to about 3;

0.01.

63. The composition of claim 39, wherein the sunscreen active is butylmethoxydibenzoylmethane, and the weight ratio of the Kaempferia galanga extract to the at least one sunscreen active is about 0.01 to 0.5:

1.

67. The composition of claim 39, wherein the Kaempferia galanga extract is a synthetic Kaempferia galanga extract.

68. The composition of claim 39, wherein the synthetic Kaempferia galanga extract has a chemical composition with about 50 percent or more commonality to a natural Kaempferia galanga extract.

78. The composition of claim 67, wherein the synthetic Kaempferia galanga extract has at least one active ingredient selected from the list consisting of borneol, camphene, carene, 3-Carene borneol, 1,8-cineole, cinnamic acid ethyl ester, ethyl p-methoxycinnamate, isoamyl p-methoxycinnamate, n-pentadecane, p-methoxycinnamic acid ethyl ester, p-methoxycinnamic acid methyl ester, and p-methoxystyrene.

43. (canceled)

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49. The composition of claim 48, wherein the Kaempferia galanga extract is present in an amount sufficient to synergistically enhance UV absorbance of the composition.

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