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Device for in vivo delivery of bioactive agents and method of manufacture thereof

  • US 20050186241A1
  • Filed: 09/09/2004
  • Published: 08/25/2005
  • Est. Priority Date: 11/17/2000
  • Status: Active Grant
First Claim
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1. An implantable drug-eluting medical device, comprising a first member having a plurality of wall surfaces defining a z-axis thickness of the first member, at least one internal chamber enclosed entirely within the z-axis thickness of the first member, at least one of a plurality of openings communicating between the internal chamber and at least one of the plurality of wall surfaces and through a portion of the z-axis thickness of the first member, a bioactive agent within the at least one internal chamber, and a plurality of second members disposed upon the at least one of the plurality of wall surfaces, at least one of the plurality of second members associated with the at least one of a plurality of openings, each of the at least one of a plurality of second members having a first position which covers and occludes an associated opening and a second position which uncovers the associated opening, the plurality of second members being capable of transitioning between the first position and the second position upon encountering a defined stimulus.

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