Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof

• US 20050186279A1
• Filed: 03/15/2005
• Published: 08/25/2005
• Est. Priority Date: 04/26/2000
• Status: Abandoned Application

• Current Assignee: PSivida Inc.
• Original Assignee: Control Delivery Systems Inc. (EyePoint Pharmaceuticals, Inc.)
• Inventors: Guo, Hong, Ashton, Paul
• Application Number:
  US11/081,142
• Publication Number:
  US 20050186279A1
• Time in Patent Office: Days
• US Class Current: 424/473
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61K 31/58 containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin digitoxin A61K31/7048
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants
• CPC Class Codes: A61K 9/0092 Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
• CPC Class Codes: A61K 9/20 Pills, tablets, discs, rods A61K9/0004, A61K9/0007, A61K9/0056, A61K9/0065 take precedence; for reconstitution of a drink A61K9/0095
• CPC Class Codes: A61K 9/5089 Processes
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 9/12 Antihypertensives
• CPC Class Codes: Y10T 29/49888 Subsequently coating

Abstract

A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained release drug delivery system to a mammalian organism in need of such treatment at an area wherein release of an effective agent is desired and allowing the effective agent to pass through the device in a controlled manner. The device includes an inner core or reservoir including the effective agent, an impermeable tube which encloses portions of the reservoir, and a permeable member at an end of the tube.

Claims

1-40. -40. (canceled)

41. A method of manufacturing a sustained drug delivery system, comprising positioning a drug core in a tube, said drug core containing a therapeutically effective amount of an active agent;

and

cross-sectionally cutting the tube into sections.

42. A method in accordance with claim 41, further comprising forming an outer layer around a portion of a section, said outer layer formed of a material selected from a permeable material and an impermeable material.

43. A method in accordance with claim 41, wherein positioning a drug core comprises positioning a said drug core in a length of tube which is sized and formed of a material so that said length of tube is dimensionally stable during said positioning.

44. The method according to claim 42, wherein the outer layer is formed by dipping, dropping, spraying, or brushing the section with a solution of polymer.

45. The method according to claim 41, wherein the tube is formed of a material selected from a permeable material and an impermeable material.