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Polymer sequencing using selectively labeled monomers and data integration

  • US 20050186576A1
  • Filed: 02/19/2004
  • Published: 08/25/2005
  • Est. Priority Date: 02/19/2004
  • Status: Abandoned Application
First Claim
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1. A method of sequencing a polymer comprising:

  • a) dividing a polymer sample into a number of polymer subsamples equal to a number of different monomer types comprising the polymer sample, wherein only one of the monomer types in each polymer subsample is partially labeled such that an average time between two adjacent labeled monomers is significantly larger than an average time between two adjacent monomers of the same type in the polymer subsample before labelling;

    b) sequentially separating each monomer from the polymer subsample;

    c) detecting the labels of each separated labeled monomer as a function of time;

    d) constructing a time map for each monomer type in each polymer subsample; and

    e) assembling the time maps into a polymer sequence.

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