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MALDI-MS analysis of nucleic acids bound to a surface

  • US 20050186579A1
  • Filed: 02/23/2004
  • Published: 08/25/2005
  • Est. Priority Date: 02/23/2004
  • Status: Abandoned Application
First Claim
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1. A method of analyzing a polynucleotide using matrix assisted laser desorption/ionization mass spectrometry, the method comprising a) obtaining the polynucleotide bound to a substrate via a linker moiety, the linker moiety comprising a triaryl methyl linker group wherein the polynucleotide is bound to a substrate via the triaryl methyl linker group;

  • b) contacting the polynucleotide bound to the substrate with a matrix material; and

    c) analyzing the polynucleotide by matrix assisted laser desorption/ionization mass spectrometry.

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