Methods for treating retinoid responsive disorders using selective inhibitors of CYP26A and CYP26B
First Claim
1. A method for treating an individual having a retinoid responsive disorder, comprising administering to said individual an effective amount of a selective CYP26B inhibitor, wherein said selective CYP26B inhibitor has at least 10-fold selectivity for CYP26B relative to CYP26A.
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Abstract
The invention provides methods for treating an individual having a retinoid responsive disorder. In one embodiment, a method involves administering to the individual an effective amount of a selective CYP26B inhibitor, the selective CYP26B inhibitor having at least 10-fold selectivity for CYP26B relative to CYP26A. In another embodiment, a method involves administering to the individual an effective amount of a selective CYP26A inhibitor, the selective CYP26A inhibitor having a chemical formula set forth in the specification. The invention further provides screening methods for identifying a selective CYP26A inhibitor or selective CYP26B inhibitor.
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Citations
74 Claims
- 1. A method for treating an individual having a retinoid responsive disorder, comprising administering to said individual an effective amount of a selective CYP26B inhibitor, wherein said selective CYP26B inhibitor has at least 10-fold selectivity for CYP26B relative to CYP26A.
- 15. A method for treating an individual having a retinoid responsive disorder, comprising administering to said individual an effective amount of a selective CYP26A inhibitor having the formula:
- 20. A method for treating an individual having a retinoid responsive disorder, comprising administering to said individual an effective amount of a selective CYP26A inhibitor having the formula:
- 25. A method for treating an individual having a retinoid responsive disorder, comprising administering to said individual an effective amount of a selective CYP26A inhibitor having the formula:
- 30. A method for treating an individual having a retinoid responsive disorder, comprising administering to said individual an effective amount of a selective CYP26A inhibitor having the formula:
- 35. A method for treating an individual having a retinoid responsive disorder, comprising administering to said individual an effective amount of a selective CYP26A inhibitor having the formula:
- 40. A method for treating an individual having a retinoid responsive disorder, comprising administering to said individual an effective amount of a selective CYP26A inhibitor having the formula:
- 45. A method for treating an individual having a retinoid responsive disorder, comprising administering to said individual an effective amount of a selective CYP26A inhibitor having the formula:
- 50. A method for treating an individual having a retinoid responsive disorder, comprising administering to said individual an effective amount of a selective CYP26A inhibitor having the formula:
- 55. A method for treating an individual having a retinoid responsive disorder, comprising administering to said individual an effective amount of a selective CYP26A inhibitor having the formula:
- 60. A method for treating an individual having a retinoid responsive disorder, comprising administering to said individual an effective amount of a selective CYP26A inhibitor having the formula:
- 65. A method for treating an individual having a retinoid responsive disorder, comprising administering to said individual an effective amount of a selective CYP26A inhibitor having the formula:
- 70. A method for treating an individual having a retinoid responsive disorder, comprising administering to said individual an effective amount of a selective CYP26A inhibitor having the formula:
Specification