Selective nerve fiber stimulation for treating heart conditions
First Claim
Patent Images
1. A method for treating a subject, comprising:
- applying, to a site of the subject, a current in respective pulse bursts in each of a plurality of cardiac cycles of the subject, the site selected from;
a vagus nerve and an epicardial fat pad;
synchronizing the bursts with the cardiac cycles; and
configuring the current so as to treat a condition of the subject selected from;
atrial arrhythmia, and atrial arrhythmia combined with heart failure.
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Abstract
Apparatus is provided that includes an electrode device, adapted to be coupled to a vagus nerve of a subject, and a control unit, adapted to drive the electrode device to apply to the vagus nerve a current that reduces heart rate variability of the subject. Also provided is a method comprising applying to a vagus nerve of a subject a current that reduces heart rate variability of the subject.
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Citations
51 Claims
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1. A method for treating a subject, comprising:
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applying, to a site of the subject, a current in respective pulse bursts in each of a plurality of cardiac cycles of the subject, the site selected from;
a vagus nerve and an epicardial fat pad;
synchronizing the bursts with the cardiac cycles; and
configuring the current so as to treat a condition of the subject selected from;
atrial arrhythmia, and atrial arrhythmia combined with heart failure. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A method for treating a subject, comprising:
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applying, to a site of the subject, a current using parameters that do not vary responsively to feedback, the site selected from;
a vagus nerve and an epicardial fat pad; and
configuring the current so as to treat a condition of the subject selected from;
atrial arrhythmia, and atrial arrhythmia combined with heart failure. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34)
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35. A method for treating a subject, comprising:
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applying a current in pulse bursts to a site of the subject selected from;
a vagus nerve and an epicardial fat pad;
setting a control parameter of a feedback algorithm governing the current application to be a number of pulses per each of the bursts; and
configuring the current so as to treat a condition of the subject selected from;
atrial arrhythmia, and atrial arrhythmia combined with heart failure. - View Dependent Claims (36, 37, 38, 39, 40, 41)
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42. A method for treating a subject, comprising:
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determining that a heart rate of the subject is greater than a threshold value;
responsively to the determination, applying a current to a site of the subject selected from;
a vagus nerve and an epicardial fat pad; and
configuring the current so as to treat a condition of the subject selected from;
atrial arrhythmia, and atrial arrhythmia combined with heart failure. - View Dependent Claims (43, 44)
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45. A method for treating a subject, comprising:
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applying a current to a vagus nerve of the subject;
configuring the current so as to stimulate only medium-diameter fibers of the vagus nerve; and
configuring the current so as to treat a condition of the subject selected from;
atrial arrhythmia, and atrial arrhythmia combined with heart failure. - View Dependent Claims (46, 47, 48)
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49. A method for treating a subject, comprising:
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applying a current to a site of the subject selected from;
a vagus nerve and an epicardial fat pad;
configuring the current so as to treat a condition of the subject selected from;
atrial arrhythmia, and atrial arrhythmia combined with heart failure; and
driving an implantable cardioverter defibrillator (ICD) to apply energy to a heart of the subject, the ICD being in communication with a control unit that drives the application of the current. - View Dependent Claims (50)
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51. A method for treating a subject, comprising:
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determining that a heart rate of the subject is greater than a threshold value that is greater than a normal heart rate;
responsively to the determination, applying a current to a site of the subject selected from;
a vagus nerve and an epicardial fat pad; and
configuring the current so as to treat a condition of the subject selected from;
atrial arrhythmia, and atrial arrhythmia combined with heart failure.
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Specification