Devices and methods for treatment of stenotic regions

• US 20050187609A1
• Filed: 01/20/2005
• Published: 08/25/2005
• Est. Priority Date: 05/23/2003
• Status: Abandoned Application

• Current Assignee: Balbir S. Brar, Harvinder Sahota
• Original Assignee: Balbir S. Brar, Harvinder Sahota
• Inventors: Brar, Balbir S., Sahota, Harvinder
• Application Number:
  US11/038,987
• Publication Number:
  US 20050187609A1
• Time in Patent Office: Days
• US Class Current: 623/1.150
• CPC Class Codes: A61B 17/12045 double occlusion, e.g. during anastomosis
• CPC Class Codes: A61B 17/12109 in a blood vessel
• CPC Class Codes: A61B 17/12136 Balloons
• CPC Class Codes: A61B 17/2202 the ultrasound transducer being inside patient's body at the distal end of the catheter
• CPC Class Codes: A61B 17/320758 with a rotating cutting instrument, e.g. motor driven A61B17/320725, A61B17/32075 and A61B17/320783 take precedence; for removing intra-ocular material A61F9/00763; endoscopic rotatable cutting instruments A61B17/32002
• CPC Class Codes: A61B 2017/1205 Introduction devices
• CPC Class Codes: A61B 2017/22001 Angioplasty, e.g. PCTA
• CPC Class Codes: A61B 2017/22051 with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation A61B2017/22048, A61B2017/3486 take precedence
• CPC Class Codes: A61B 2017/22054 with two balloons
• CPC Class Codes: A61B 2017/22061 for spreading elements apart
• CPC Class Codes: A61F 2/88 the wire-like elements formed as helical or spiral coils forming a net-like or mesh-like structure A61F2/90
• CPC Class Codes: A61F 2/885 comprising a coil including a plurality of spiral or helical sections with alternate directions around a central axis
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61F 2002/9583 Means for holding the stent on the balloon, e.g. using protrusions, adhesives or an outer sleeve
• CPC Class Codes: A61F 2230/0078 hyperboloidal
• CPC Class Codes: A61F 2250/0039 differing in diameter
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61L 2300/416 Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
• CPC Class Codes: A61L 2300/61 : containing two or more active agents in different layers
• CPC Class Codes: A61L 29/16 : Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/16 : Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61M 2025/0096 : being laterally outward extensions or tools, e.g. hooks or fibres
• CPC Class Codes: A61M 25/10 : Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00

Abstract

An improved method and devices for preventing restenosis are provided. A multiple drug combination eluting stent is provided. The stent includes a plurality of drugs which interact to combat restenosis. In some embodiments, the drugs are delivered simultaneously, while in other embodiments, the drugs are delivered sequentially.

Claims

1. A stent comprising:

an expandable tubular member having a proximal end, a distal end, and a center portion;

a first drug layer on the expandable tubular member, the first drug layer comprising an anticancer drug.

2. The stent of claim 1, wherein the first drug layer comprises Alchemix.

3. The stent of claim 1, wherein the first drug layer comprises a polymer coating.

4. The stent of claim 1, further comprising a second drug layer.

5. The stent of claim 4, wherein the second drug layer comprises an anticancer drug.

6. The stent of claim 5, wherein the second drug layer comprises an anticancer drug that is the same anticancer drug as that of the first drug layer.

7. The stent of claim 5, wherein the anticancer drug of the second drug layer is Alchemix.

8. A method of providing an anticancer drug to a patient comprising:

delivering a stent to a treatment site; and

releasing the anticancer drug provided on the stent at the treatment site.

9. The method of claim 8, wherein the anticancer drug released at the treatment site is Alchemix.

10. A method of providing a medicated stent comprising:

providing a stent that is configured to receive an anticancer drug thereon; and

providing an anticancer drug that is applicable tostent;

wherein the anticancer drug configured to be released into a patient upon application of the stent within the patient.

11. The method of claim 10, wherein the anticancer drug is Alchemix.

12. The method of claim 10, wherein the anticancer drug is applied to the stent with a polymer coating.