Method and chemical sensor for determining concentrations of hydrogen peroxide and its precusor in a solution
First Claim
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1. A chemical sensor comprising a transducer which is able to conduct an electric current and a mixed-valence metal oxide deposited on a surface of the transducer, wherein said mixed-valence metal oxide has a formula as follows:
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MxOy wherein M is a transition metal and has two or more than two different valences;
x and y represent moles of said transition metal, M, and oxygen, respectively, provided that 2y=(x1)(z1)+(x2)(z2) . . . +(xn)(zn), and x1+x2+ . . . +xn=x, wherein z1, z2, . . . zn represent the valences of M;
x1, x2, . . . xn represent moles of M having valences of z1, z2, . . . zn, respectively, and n is a positive integer.
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Abstract
A new electrochemical sensor for determining hydrogen peroxide concentration having a mixed-valence metal oxide of MxOy deposited on an electrode surface thereof is disclosed, wherein M is a transition metal and has two or more than two valences. MxOy, for example, is M3O4 where M is Mn, Fe, Co or Pb, Tb4O7 or Pr6O11. Further, this invention also discloses an electrochemical sensor for determining a concentration of a hydrogen peroxide precursor, wherein a catalyst is immobilized in the matrix or on the surface of the mixed-valence metal oxide on the electrode. In a typical biochemical system, the catalyst can be a glucose oxidase and blood glucose is catalyzed to form hydrogen peroxide, so that the concentration of blood glucose is determined.
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Citations
53 Claims
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1. A chemical sensor comprising a transducer which is able to conduct an electric current and a mixed-valence metal oxide deposited on a surface of the transducer, wherein said mixed-valence metal oxide has a formula as follows:
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MxOywherein M is a transition metal and has two or more than two different valences;
x and y represent moles of said transition metal, M, and oxygen, respectively, provided that 2y=(x1)(z1)+(x2)(z2) . . . +(xn)(zn), and x1+x2+ . . . +xn=x, wherein z1, z2, . . . zn represent the valences of M;
x1, x2, . . . xn represent moles of M having valences of z1, z2, . . . zn, respectively, and n is a positive integer.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A method for measuring H2O2 concentration in a solution comprising the following steps:
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a) contacting a counter electrode, a reference electrode and a working electrode with a solution, wherein said working electrode comprises a transducer which is able to conduct an electric current and a mixed-valence metal oxide deposited on a surface of the transducer, wherein said mixed-valence metal oxide has a formula as follows;
MxOywherein M is a transition metal and has two or more than two different valences;
x and y represent moles of said transition metal, M, and oxygen, respectively, provided that 2y=(x1)(z1)+(x2)(z2) . . . +(xn)(zn), and x1+x2+ . . . +xn=x, wherein z1, z2, . . . zn represent the valences of M;
x1, x2, . . . xn represent moles of M having valences of z1, z2, . . . zn, respectively, and n is a positive integer;
b) obtaining an electric current from the working electrode by apmerometry, wherein a fixed potential between the working electrode and the reference electrode is maintained, and said fixed potential ranges from +0.2 V to −
0.3V when the reference electrode is 3 M KCl Ag/AgCl electrode; and
c) comparing the electric current from b) with electric currents obtained from solutions having known H2O2 concentrations under substantially the same operating conditions and the same fixed potential used in steps a) and b), so that a concentration of H2O2 in said solution is calculated from said comparison. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A method for measuring a concentration of a hydrogen peroxide precursor in a solution comprising the following steps:
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a) contacting a counter electrode, a reference electrode and a working electrode with a solution, wherein said working electrode comprises a transducer which is able to conduct an electric current, a catalyst deposited on a surface of the transducer, said catalyst being able to catalyze a H2O2 precursor to undergo a reaction producing H2O2, and a mixed-valence metal oxide deposited on the surface of the transducer, wherein said mixed-valence metal oxide has a formula as follows;
MxOywherein M is a transition metal and has two or more than two different valences;
x and y represent moles of said transition metal, M, and oxygen, respectively, provided that 2y=(x1)(z1)+(x2)(z2) . . . +(xn)(zn), and x1+x2+ . . . +xn=x, wherein z1, z2, . . . zn represent the valences of M;
x1, x2, . . . xn represent moles of M having valences of z1, z2, . . . zn, respectively, and n is a positive integer;
b) obtaining an electric current from the working electrode by apmerometry, wherein a fixed potential between the working electrode and the reference electrode is maintained, and said fixed potential ranges from +0.2 V to −
0.3V when the reference electrode is 3 M KCl Ag/AgCl electrode; and
c) comparing the electric current from b) with electric currents obtained from solutions having known concentrations of said H2O2 precursor under substantially the same operating conditions and the same fixed potential used in steps a) and b), so that a concentration of H2O2 precursor in said solution is calculated from said comparison. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53)
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Specification
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Current AssigneeTamkang University
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Original AssigneeTamkang University
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InventorsLeu, Hoang Jyh, Lin, Meng Shan
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Application NumberUS10/948,252Publication NumberTime in Patent OfficeDaysField of SearchUS Class Current205/782CPC Class CodesC12Q 1/004 mediator-assistedC12Q 1/005 involving specific analytes...
