Method for short-term and long-term drug dosimetry
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Abstract
Methods for the treatment of interferon-response disorders by administration of an interferon alone or in combination with adjunctive therapy are described. The invention encompasses providing to a patient both a formulation of an interferon that is suitable for short-term administration and a formulation of an interferon associated with a sustained release delivery system that is suitable for long-term administration. A principal advantage of the method is that responsiveness to treatment can be ascertained with short-term dosimetric techniques using one formulation of an interferon, which permits the appropriate selection of a dose that is both effective and safe for long-term administration using the second formulation.
65 Citations
84 Claims
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1-64. -64. (canceled)
- 65. A method of treating an interferon-responsive disorder in a warm-blooded animal, comprising administering to the animal via an internally implanted pump that is not externally programmed an amount of an interferon determined from short-term administration of the same or a different interferon to be suitable to treat the disorder.
- 81. A method for individualizing doses of an interferon in the treatment of interferon responsive disorders in a warm-blooded animal, comprising administering to an individual animal via an internally implanted pump that is not externally programmed an amount of an interferon determined from short-term administration of the same or a different interferon in a plurality of animals to be suitable to treat the disorder.
Specification