Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
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Abstract
Combinations of hydrophilic and hydrophobic entities in a biodegradable sustained release implant are shown to modulate each other'"'"'s rate of release. Formulations of a therapeutically active agent and modulator provide substantially constant rate of release for an extended period of time.
108 Citations
38 Claims
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1-9. -9. (canceled)
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10. A sustained release device including a corticosteroid disposed therein, which device is dimensioned for implantation in the vitreal chamber or the posterior segment of a patient'"'"'s eye and configured to have a release rate for said corticosteroid of at least about 1 μ
- g per day over a time course of at least 4 weeks after implantation, which release rate results in an aqueous humor corticosteroid concentration less than one tenth the vitreous corticosteroid concentration.
- View Dependent Claims (11, 12, 13, 14)
- 15. A sustained release device including a corticosteroid disposed therein, which device is dimensioned for implantation in the vitreal chamber or the posterior segment of a patient'"'"'s eye and configured to have a release rate for said corticosteroid to produce a sustained and therapeutic concentration of said corticosteroid over a time course of at least 4 weeks effective for reducing diabetic retinopathy, which release rate results in an insignificant or undetectable aqueous humor corticosteroid concentration over said time course.
- 19. A sustained release device including a steroid disposed therein, which device is dimensioned for implantation in the vitreal chamber or the posterior segment of a patient'"'"'s eye and configured to release a therapeutically effective amount of steroid, which amount does not produce toxicity.
- 21. A method for treating or preventing ocular diseases, comprising administering a corticosteroid to a posterior segment of an eye to provide sustained release of a therapeutic concentration of said corticosteroid in the vitreous of the eye while not exceeding a non-toxic concentration of corticosteroid in the aqueous of the eye.
- 32. A method for treating or preventing ocular diseases, comprising administering corticosteroid to a posterior segment of an eye to produce a sustained therapeutic concentration of corticosteroid for a period of at least 1 month, wherein the aqueous concentration of corticosteroid is less than the vitreous concentration of corticosteroid during said period.
Specification