Bioarray chip reaction apparatus and its manufacture
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Accused Products
Abstract
A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the cavity to contact the probes. Accordingly, a commercially feasible device for use in high throughput assay systems is provided.
106 Citations
120 Claims
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1-92. -92. (canceled)
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93. An apparatus for mixing a fluid, the apparatus comprising:
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a first substrate comprising a first inner surface functionalized with a microarray of reactive moieties;
a substantially parallel second substrate also comprising a second inner surface, wherein said first and second inner surfaces bound a closed chamber there between, said chamber adapted to retain a quantity of fluid so that the fluid is in contact with both surfaces;
at least one bubble disposed within said chamber; and
means for moving the chamber so that the bubble moves relative to the fluid to effect mixing of the fluid. - View Dependent Claims (94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106)
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107. An apparatus for mixing a fluid, the apparatus comprising:
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a first substrate comprising a first inner surface functionalized with an array of reactive moieties;
a substantially parallel second substrate also comprising a second inner surface, wherein said first and second inner surfaces bound a closed chamber there between, said chamber adapted to retain a quantity of fluid so that the fluid is in contact with both surfaces;
at least one bubble disposed within said chamber; and
means for moving the chamber so that the bubble moves relative to the fluid to effect mixing of the fluid. - View Dependent Claims (108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120)
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Specification