Treatment of inflammatory disease by cleaving TNF receptors
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Abstract
The biological effects of the cytokine TNF are mediated by binding to receptors on the surface of cells. This disclosure describes new proteins and polynucleotides that promote enzymatic cleavage and release of TNF receptors. Also provided are methods for identifying additional compounds that influence TNF receptor shedding. As the active ingredient in a pharmaceutical composition, the products of this invention increase or decrease TNF signal transduction, thereby alleviating the pathology of disease.
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50 Claims
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1-32. -32. (canceled)
- 33. A method for treating arthritis or reducing inflammation in a subject, comprising administering to the subject a means for cleaving TNF receptors from the surface of cells.
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