Microfabricated flowthrough porous apparatus for discrete detection binding reactions
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Abstract
An improved microfabricated apparatus for conducting a multiplicity of individual and simultaneous binding reactions is described. The apparatus comprises a substrate on which are located discrete and isolated sites for binding reactions. The apparatus is characterized by discrete and isolated regions that extend through said substrate and terminate on a second surface thereof such that when a test sample is allowed to the substrate, it is capable of penetrating through each such region during the course of said binding reaction. The apparatus is especially useful for sequencing by hybridization of DNA molecules.
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Citations
34 Claims
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1-20. -20. (canceled)
- 21. A microfabricated device comprising a substrate containing a multiplicity of discrete and isolated regions arrayed across a surface, each of said discrete and isolated regions containing homogeneous samples of biomolecules of pre-determined structures fixed thereto, wherein said multiplicity of discrete and isolated regions are contained in a sample well.
- 26. A microfabricated device comprising a plurality of genosensors, wherein each genosensor is contained in a sample well.
Specification