Trophoblast cell preparations
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Abstract
Stable pluripotent trophoblast stem (TS) cell lines and uses of the cell lines are described. The cell lines comprise cells that (i) are capable of indefinite proliferation in vitro in an undifferentiated state; and (ii) are capable of differentiation into cells of the trophoblast lineage in vivo.
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Citations
21 Claims
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1. A stable pluripotent trophoblast stem (TS) cell line.
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2. A purified preparation of trophoblast stem cells which (i) are capable of indefinite proliferation in vitro in an undifferentiated state;
- and (ii) are capable of differentiation into cells of the trophoblast lineage in vivo.
- View Dependent Claims (3, 4, 5, 19, 20)
- 6. (canceled)
- 8. A method for producing a trophoblast cell line comprising culturing early postimplantation trophoblast cells or cells of a blastocyst on a feeder layer in the presence of FGF4, and a co-factor.
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21-22. -22. (canceled)
Specification