System and method for endoscopic optical constrast imaging using an endo-robot

• US 20050192478A1
• Filed: 01/27/2005
• Published: 09/01/2005
• Est. Priority Date: 02/27/2004
• Status: Abandoned Application

• Current Assignee: Siemens Medical Solutions USA Incorporated (Siemens AG)
• Original Assignee: Siemens Medical Solutions USA Incorporated (Siemens AG)
• Inventors: Abraham-Fuchs, Klaus, Williams, James P.
• Application Number:
  US11/044,575
• Publication Number:
  US 20050192478A1
• Time in Patent Office: Days
• US Class Current: 600/160
• CPC Class Codes: A61B 1/00016 using wireless means
• CPC Class Codes: A61B 1/00029 externally powered, e.g. wireless
• CPC Class Codes: A61B 1/00158 using magnetic field
• CPC Class Codes: A61B 1/041 Capsule endoscopes for imaging
• CPC Class Codes: A61B 1/0638 providing two or more wavelengths
• CPC Class Codes: A61B 1/0676 at distal tip of an endoscope
• CPC Class Codes: A61B 1/0684 using light emitting diodes [LED]
• CPC Class Codes: A61B 2560/0219 of externally powered implanted units
• CPC Class Codes: A61B 5/062 using magnetic field
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61N 2005/0605 Ear
• CPC Class Codes: A61N 2005/0609 Stomach and/or esophagus
• CPC Class Codes: A61N 2005/061 Bladder and/or urethra
• CPC Class Codes: A61N 2005/0661 ultraviolet
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent
• CPC Class Codes: B82Y 10/00 Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

A system and method for endoscopic optical imaging using an endo-robot is provided. The method for performing endoscopic optical imaging using a capsule endoscope comprises: navigating the capsule endoscope through a lumen of a patient that has been introduced with an optical contrast agent; illuminating a portion of the lumen that is not penetrable by an external light source with light emitted from the capsule endoscope to enhance an image intensity of the portion of the lumen; and powering the capsule endoscope with an externally applied magnetic field.

Claims

1. A method for performing endoscopic optical imaging using a capsule endoscope, comprising:

navigating the capsule endoscope through a lumen of a patient that has been introduced with an optical contrast agent;

illuminating a portion of the lumen that is not penetrable by an external light source with light emitted from the capsule endoscope to enhance an image intensity of the portion of the lumen; and

powering the capsule endoscope with an externally applied magnetic field.

2. The method of claim 1, further comprising:

administering the optical contrast agent to the lumen of the patient.

3. The method of claim 2, wherein the optical contrast agent is administered by one of intravenous injection, oral administration, rectal administration, and inhalation.

4. The method of claim 1, wherein the optical contrast agent is one of indocyanine green, methelyne blue and fluorescein.

5. The method of claim 1, wherein the lumen is one of a gastrointestinal tract, pancreas, bronchi, larynx, trachea, sinus, ear canal, blood vessel, urethra and bladder.

6. The method of claim 1, further comprising:

inserting the capsule endoscope into the lumen of the patient.

7. The method of claim 6, wherein the capsule endoscope is inserted by one of oral insertion, rectal insertion, and through a sluice.

8. A method for treating a pathology using a capsule endoscope, comprising:

navigating the capsule endoscope through a lumen that has been introduced with a tumor-targeted contrast agent;

identifying a tumor in the lumen made visible by the tumor-targeted contrast agent using a viewing device of the capsule endoscope;

treating the tumor with phototherapy using an illumination device of the capsule endoscope; and

powering the capsule endoscope with an externally applied magnetic field..

9. The method of claim 8, wherein the tumor-targeted contrast agent is one of a metal nanopartical, quantum dot, and organic fluorescent dye.

10. The method of claim 8, wherein the tumor-targeted contrast agent is coupled to a monoclonal antibody to bind to a tumor.

11. The method of claim 8, wherein the tumor is one of a nodule, lesion, polyp, pre-cancerous growth, or cancerous growth.

12. The method of claim 8, wherein the phototherapy is one of ultraviolet light B (UVB) therapy, photochemotherapy, and photodynamictherapy.

13. A system for performing endoscopic optical imaging, comprising:

a capsule endoscope, comprising;

a linear magnet for enabling the capsule endoscope to be moved inside a lumen of a patient;

a camera for capturing images inside the lumen, an illuminator for illuminating the inside of the lumen;

a controller for controlling the camera and the illuminator;

a transceiver for performing one of transmitting the images captured by the camera and receiving commands from outside the patient; and

a power supply for receiving an inductive charge from an externally applied magnetic field; and

a magnetic control system, comprising;

a first and second magnet tube for generating the magnetic field for controlling the movement of the capsule endoscope inside the lumen, a gradient amplifier for changing the direction of the magnetic field;

a plurality of sensors for receiving location and orientation signals from the capsule endoscope;

a location measuring device for processing the location and orientation signals from the capsule endoscope; and

a control unit for controlling the movement of the capsule endoscope using the received location and orientation signals.

14. The system of claim 13, wherein the linear magnet is a superconducting magnet.

15. The system of claim 13, wherein the illuminator is one of an infrared (IR) light emitting device, light emitting diode (LED), high-performance three-color LED, and micro-fluorescent lamp.

16. The system of claim 13, wherein the illuminator is capable of treating a tumor in the lumen with phototherapy.

17. The system of claim 13, wherein the power supply is an accumulator.

18. The system of claim 13, wherein the capsule endoscope further comprises:

a drug delivery device for delivering drugs to a tumor inside the lumen.

19. The system of claim 13, wherein the capsule endoscope further comprises:

a biopsy gun for acquiring samples of a suspected pathological site inside the lumen.

20. The system of claim 13, wherein the capsule endoscope further comprises:

a surgical device for performing one of applying a mechanical force to a suspected pathological site inside the lumen to determine the elasticity of the suspected pathological site and for removing a tumor from the lumen.

21. The system of claim 13, wherein the capsule endoscope further comprises:

a sound generator for generating sound waves to be targeted at a suspected pathological site inside the lumen.

22. The system of claim 13, wherein the capsule endoscope further comprises:

a measuring device for measuring one of temperature, electrical conductivity, pressure, and chemical levels inside the lumen.

23. The system of claim 13, wherein the location measuring device is a transponder.

24. The system of claim 13, wherein the magnetic control system further comprises:

a reception unit for receiving the captured images from the capsule endoscope and for transmitting the captured images to the control unit.

25. The system of claim 13, wherein the magnetic control system further comprises:

a bed for receiving the patient.

26. A method for performing an endoscopic examination using an endo-robot, comprising:

administering a contrast agent to a lumen of a patient;

introducing the endo-robot into the lumen;

navigating the endo-robot through the lumen;

illuminating a portion of the lumen that is not penetrable by an external light source using the endo-robot;

identifying a tumor in the portion of the lumen using the endo-robot;

treating the tumor with phototherapy using the endo-robot; and

powering the endo-robot with an externally applied magnetic field.