Methods, apparatus and charged chemicals for control of ions, molecules or electrons

• US 20050192528A1
• Filed: 01/04/2005
• Published: 09/01/2005
• Est. Priority Date: 01/08/2004
• Status: Abandoned Application

• Current Assignee: Robert Tapper
• Original Assignee: Robert Tapper
• Inventors: Tapper, Robert
• Application Number:
  US11/029,904
• Publication Number:
  US 20050192528A1
• Time in Patent Office: Days
• US Class Current: 604/20
• CPC Class Codes: A24D 3/06 Use of materials for tobacco smoke filters
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61N 1/0444 Membrane
• CPC Class Codes: A61N 1/0448 Drug reservoir
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/08 for glucose homeostasis pancreatic hormones A61P5/48
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 7/00 Drugs for disorders of the blood or the extracellular fluid
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

A system including methods, apparatus, components and charged chemicals for control of ions, molecules or electrons whereby charged membranes, testing devices, electrode patch structures and the like utilize features of the invention for control of flow in a wide variety of new and improved medical, testing, cosmetic, personal care, flow delivery applications and the like.

Claims

1. A flow control system, comprising:

a support member; and

charged chemicals of either negative and/or positive polarity on said support member;

whereby said charged chemicals control the flow of ions, molecules or electrons.

2. A flow control system as recited in claim 1, wherein said support member includes membranes.

3. A flow control system as recited in claim 1, wherein said support member includes felt pads made of natural or synthetic fibers.

4. A flow control system as recited in claim 1, wherein said support member includes impregnated filter paper.

5. A flow control system as recited in claim 1, wherein said support member includes a liquid or gel form.

6. A flow control system as recited in claim 1, wherein said support member includes any materials that control the flow of ions, molecules or electrons.

7. A system as set forth in claim 1, wherein said charged chemicals of either negative and/or positive polarity are formulated with an increased concentration of the charged chemicals causing either negative or positive polarity to increase their effectiveness.

10. A fluid delivery patch as recited in any of claims 1-9 and further including:

additional electrical supply means to further enhance said charged membrane.

12. In a system as recited in any of claims 1-11, the use of electrical currents greater than the traditional 0.5 ma per cm.

8. In an iontophoretic drug delivery system, the combination comprising:

an electrode;

charged chemicals in solution as an integral part of a support member such as felt pad(s) or a membrane(s) for prevention of a) injurious chemicals emanating from said electrode from reaching the skin, b) sodium hydroxide developed at the negative terminal from reaching the skin with either a negatively charged or positively charged intervenor between the skin and said electrode in an electrically conductive circuit, c) hydrochloric acid generated at the positive electrode terminal from reaching the skin, with either positively charged or negatively charged chemicals on an appropriate support intervenor spaced between the electrode and the skin in an electrically conductive system.

11. A system as recited in claim 8 wherein said chemically charged interventor(s) act as a reservoir or storage area for the drug to be delivered.

9. A fluid delivery patch for application to a biological subject, comprising:

a chemical to be delivered to the subject;

at least one charged membrane incorporating or adjacent said chemical for electrically driving said chemical into the subject;

and support means for supporting said membrane and said chemical in a proximity to the subject suitable for proper chemical delivery to the subject.

13. Apparatus adapted for placement within a biological subject, comprising:

a stent; and

a coating of electrically charged chemicals deposited on said stent.

14. Apparatus as recited in claim 13, wherein said chemicals may be either positive or negative or both to cause elution and prevent restenosis.

15. In an AC iontophoretic device, the use of charged chemicals on an intervenor or in combination with both positive and negative polarities.

16. In an iontophoresis or reverse iontophoresis system, the combination comprising:

electrically charged membranes between the skin, and an output electrode as the conductive element when wetted with distilled water, whereby clutter from conductive chemicals that may be added to enhance transport is avoided.

17. In a drug delivery system, the use of a small amount of glucose in solution with insulin for substantial amplification in a powered environment using charged membranes.

18. In an improved cigarette filter:

the use of charged chemicals on the filters positioned between the tobacco and the end held in the mouth of a smoker, to prevent the migration of deleterious tobacco chemicals from entering the mouth upon inhaling.

19. An improved cigarette filter as recited in claim 18, including the use of charged chemicals of either polarity or in combination on impregnated filter paper or membranes, as an intervenor between tobacco and mouth to prevent polarized harmful chemicals from reaching the mouth.

20. In a medical application, the use of a chemically charged bandage or the like to enhance and speed wound healing.

21. For dental applications, the use of a charged chemical of negative polarity to infuse the fluoride in a toothpaste below the tooth'"'"'s surface and gum to prevent cavities and disease.

22. For use in cosmetic and personal care applications, the method comprising:

use of charged chemicals in liquid form as a spray to be applied over a moisturizer base or any other skin conditioner.

23. A new and improved method, comprising:

using positively charged salicylic acid in combination with negatively charged sulfonic acid or carboxyl acid or the like to bind to each other and thus limit migration of the salicylic acid beneath the epidermis;

24. A new and improved method, comprising:

use of salicylic acid as a skin spray as part of a two component system wherein a negatively charged spray follows.

25. A method for cosmetic and personal care applications, comprising:

the use of charged chemicals in formulation with like-charged skin improvement material, whereby the repelled skin improvement materials will be infused deeper into the skin.

26. A non-invasive diagnostic withdrawal device using a charged or polarized membrane(s), one end of which is positioned to touch the skin and the other end touching an electrode, whereby withdrawal is enhanced and skin injury is mitigated.

27. A withdrawal device as recited in claim 26, wherein the height of said membrane is increased to facilitate the use of currents above 0.5 ma per cm².

28. A withdrawal device as recited in claim 26, and further including:

a positively charged wetted membrane to prevent skin injury by stopping the sodium hydroxide ions emitted from the negative electrode in an electrically conductive circuit.

29. A device as set forth in claim 26, wherein target withdrawn glucose analyte passes through said membrane to the end that touches a negative electrode which becomes the critical pick-up point for a glucose monitor to read.

30. A device as set forth in claim 26, wherein said charged membrane is constructed in a rolled form so that one end of the rolled membrane touches the skin and the other end touches said electrode, whereby the withdrawn analyte sees only straight line, unbroken surfaces while migrating to said electrode.

31. A device as recited in any of claims 26-30, including provision of a high pH from the electrode that attracts the glucose to the point of signal deposition.

32. A device as recited in claim 31, wherein the membrane end in contact with said electrode is the pick-up point for the withdrawn glucose which is then placed in contact with a monitor'"'"'s strip for analysis or direct reading.

33. A device as recited in claim 26, wherein said electrode includes a screen made of stainless steel to evenly disperse sodium hydroxide and pH.

34. A device as recited in claim 26, wherein a dosimetry circuit is provided that precisely controls the analyte withdrawal quantity based on time and current.

35. A device as recited in claim 26, and further including:

a calibration switch in the form of a multi-position switch that selects the withdrawal time/current to match the highs, lows, and in-between time glucose levels of a patient caused by meals, physical exercise, or insulin dose.

36. A multi-position switch as recited in claim 35, having the following selections:

Position 1 (1-2 hours after meals), Position 2 (2-3 hours after meals), and Position 3 (3-4 hours after meals).

37. In an apparatus as recited in either of claims 35 or 36, the improvement comprising:

readout means for obtaining a precise reading when the withdrawn glucose specimen is processed at a strip and provides a readout based on the glucose concentration or density in the withdrawn interstitial fluid.

43. A device as recited in claim 26 and further including:

the use of two membranes, one charged or conductive and the other nonconductive in direct contact with each other and spaced between the skin and the electrode.

44. A device as recited in claim 43, wherein said nonconductive membrane is placed in contact with the skin and said charged membrane in contact with the electrode to complete the circuit.

45. A device as recited in claim 26, and further including:

a wool felt nib as an intervenor between the skin and said electrode to prevent the passage of sodium hydroxide from the negative electrode to the skin.

46. A device as recited in claim 45 wherein said nib may be coated with charged chemicals.

38. A new and improved method, comprising:

mixing a positively charged chemical with an antiperspirant and

applying the mixture to a biological subject,

whereby said charged chemical will drive said antiperspirant deep down the eccrine sweat duct for greater effectiveness than topical application.

39. A method as recited in claim 38, wherein said antiperspirant is aluminum chloride and the like.

40. A new and improved method, comprising:

applying to a subject a first spray containing a suitable antiperspirant;

following said first spray with a second spray of a positively charged chemical to infuse said antiperspirant deeply into said subject.

41. A method as recited in claim 40, wherein said antiperspirant is aluminum chloride and the like.

42. A new and improved method, comprising:

applying to a subject a first spray containing a suitable substance for infusion into the subject;

following said first spray with a second spray of a charged chemical to infuse said substance deeply into the subject.

47. Each and every novel feature and/or combination of features herein disclosed.