Method and apparatus for needle-less injection with a degassed fluid

• US 20050192530A1
• Filed: 06/02/2004
• Published: 09/01/2005
• Est. Priority Date: 04/13/2001
• Status: Abandoned Application

• Current Assignee: PenJet Corp.
• Original Assignee: PenJet Corp.
• Inventors: Castellano, Thomas P.
• Application Number:
  US10/859,541
• Publication Number:
  US 20050192530A1
• Time in Patent Office: Days
• US Class Current: 604/70
• CPC Class Codes: A61M 2005/2013 triggering of discharging means by contact of injector with patient body
• CPC Class Codes: A61M 2005/3104 Caps for syringes without needle
• CPC Class Codes: A61M 2005/3123 having air entrapping or venting means, e.g. purging channels in pistons
• CPC Class Codes: A61M 2005/3142 Modular constructions, e.g. supplied in separate pieces to be assembled by end-user
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/582 by tactile feedback
• CPC Class Codes: A61M 2205/583 by visual feedback
• CPC Class Codes: A61M 5/204 connected to external reservoirs for multiple refilling
• CPC Class Codes: A61M 5/2053 Media being expelled from injector by pressurised fluid or vacuum for infusion A61M5/145, A61M5/155
• CPC Class Codes: A61M 5/2448 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
• CPC Class Codes: A61M 5/3129 Syringe barrels A61M5/3205 and A61M5/50 take precedence
• CPC Class Codes: A61M 5/484 Regulating injection pressure

Abstract

Apparatuses and methods are described for administering a needle-less injection of a degassed fluid. Prior to filling, or after filling but prior to administration of a needle-less injection, gas is removed from the fluid to create a degassed fluid. A needle-less injection may then be performed with a reduced risk of discomfort to the recipient of the injection and with lower potential for the creation of a subdermal hematoma as a result of the injection. A wide variety of needle-less injectors may be used in accordance with various embodiments of the present invention.

Claims

1. A needle-less injector to administer an injection of a degassed fluid, said needle-less injector containing a degassed fluid.

2. The needle-less injector of claim 1, further comprising an ampoule to contain said degassed fluid.

3. The needle-less injector of claim 2, wherein said ampoule is configured to be filled with said degassed fluid and stored separate from remaining components of said needle-less injector prior to use of said needle-less injector to administer a needle-less injection.

4. The needle-less injector of claim 1, wherein upon actuation of said needle-less injector said degassed fluid is entirely evacuated from said needle-less injector.

5. The needle-less injector of claim 1, wherein upon actuation of said needle-less injector said degassed fluid is partially evacuated from said needle-less injector.

6. The needle-less injector of claim 1, wherein said degassed fluid is selected from the group consisting of liquids, solutions, suspensions, mixtures, diluents, reagents, solvents, emulsions, pharmaceutical vehicles, pharmaceutical excipients, vaccines, injectable medications, drugs, pharmaceutical agents, nucleotide based medications, saline solution, non-medicinal fluids administered as a placebo in a clinical study, two-component injectates, and combinations thereof.

7. The needle-less injector of claim 1, wherein said needle-less injector is powered by a power source selected from the group consisting of a spring, pressurized gas, electricity, and combinations thereof.

8. The needle-less injector of claim 1, said needle-less injector containing a lyophilized product to mix with said degassed fluid.

9. A method of administering a needle-less injection of a degassed fluid to a recipient, comprising:

providing a needle-less injector containing a degassed fluid; and

administering a needle-less injection of said degassed fluid with said needle-less injector to said recipient.

10. The method of claim 9, wherein providing a needle-less injector containing a degassed fluid further comprises:

mating an ampoule containing said degassed fluid to remaining components of said needle-less injector.

11. The method of claim 9, wherein administering said needle-less injection of said degassed fluid to said recipient further comprises:

entirely evacuating said degassed fluid from said needle-less injector into said recipient.

12. The method of claim 9, wherein administering said needle-less injection of said degassed fluid to said recipient further comprises:

partially evacuating said degassed fluid from said needle-less injector into said recipient.

13. The method of claim 9, wherein said degassed fluid is selected from the group consisting of liquids, solutions, suspensions, mixtures, diluents, reagents, solvents, emulsions, pharmaceutical vehicles, pharmaceutical excipients, vaccines, injectable medications, drugs, pharmaceutical agents, nucleotide based medications, saline solution, non-medicinal fluids administered as a placebo in a clinical study, two-component injectates, and combinations thereof.

14. The method of claim 9, wherein said needle-less injector is powered by a power source selected from the group consisting of a spring, pressurized gas, electricity, and combinations thereof.

15. The method of claim 9, wherein administering said needle-less injection of said degassed fluid with said needle-less injector to said recipient further comprises:

mixing said degassed fluid with a lyophilized product contained in said needle-less injector to create a mixture; and

administering said mixture to said recipient.

16. A method of providing a needle-less injector filled with an injectate that is substantially free of gas pockets, comprising:

providing an injectate that is a degassed fluid; and

filling said needle-less injector with said injectate.

17. The method of claim 16, wherein filling said needle-less injector with said injectate further comprises:

providing an ampoule;

filling said ampoule with said injectate; and

mating said ampoule to remaining components of said needle-less injector.

18. The method of claim 16, wherein said degassed fluid is selected from the group consisting of liquids, solutions, suspensions, mixtures, diluents, reagents, solvents, emulsions, pharmaceutical vehicles, pharmaceutical excipients, vaccines, injectable medications, drugs, pharmaceutical agents, nucleotide based medications, saline solution, non-medicinal fluids administered as a placebo in a clinical study, two-component injectates, and combinations thereof.

19. The method of claim 16, wherein said needle-less injector is powered by a power source selected from the group consisting of a spring, pressurized gas, electricity, and combinations thereof.

20. The method of claim 16, wherein said needle-less injector contains a lyophilized product to mix with said injectate.