Combinations of antiseptic and antibiotic agents containing medical devices

• US 20050192547A1
• Filed: 07/30/2003
• Published: 09/01/2005
• Est. Priority Date: 01/31/2002
• Status: Abandoned Application

• Current Assignee: Lester Sampath, Shanta Modak, Suhas Tambe
• Original Assignee: Lester Sampath, Shanta Modak, Suhas Tambe
• Inventors: Tambe, Suhas, Modak, Shanta M., Sampath, Lester A.
• Application Number:
  US10/633,204
• Publication Number:
  US 20050192547A1
• Time in Patent Office: Days
• US Class Current: 604/265
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/10 Macromolecular compounds
• CPC Class Codes: A01N 25/34 Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
• CPC Class Codes: A01N 37/44 containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
• CPC Class Codes: A01N 47/44 Guanidine; Derivatives thereof
• CPC Class Codes: A01N 59/16 Heavy metals; Compounds thereof
• CPC Class Codes: A61L 2300/102 Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
• CPC Class Codes: A61L 2300/202 with halogen atoms, e.g. triclosan, povidone-iodine
• CPC Class Codes: A61L 2300/206 Biguanides, e.g. chlorohexidine
• CPC Class Codes: A61L 2300/208 Quaternary ammonium compounds
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/406 Antibiotics
• CPC Class Codes: A61L 2300/45 Mixtures of two or more drugs, e.g. synergistic mixtures
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence

Abstract

The present invention relates to compositions comprising a combination of one or more antiseptic and an antibiotic. It is based, at least in part, on the discovery that such combinations tend to deter the formation of antibiotic-resistant organisms. In preferred, nonlimiting embodiments of the invention, the antibiotic is minocycline and the antiseptic is a chlorhexidine compound, triclosan, or benzalkonium chloride, and in particular embodiments, a silver salt or a bismuth salt is added. Examples of specific, nonlimiting embodiments of the invention include combinations of (i) minocycline, triclosan, and a bismuth salt; (ii) minocycline, a chlorhexidine compound, and a bismuth salt; and (iii) minocycline, benzalkonium chloride, and a bismuth salt. The present invention further provides for articles, such as, but not limited to, medical articles, which have been treated with or which otherwise comprise a combination of antiseptic and antibiotic.

Claims

1. An anti-infective medical article prepared by exposing a polymer-containing medical article, for an effective period of time, to a treatment solution comprising between 1 and 8 percent (weight/volume) of minocycline and between 1 and 8 percent (weight/volume) of a chlorhexidine compound.

2. The anti-infective medical article of claim 1, where the treatment solution further comprises a bismuth salt at a concentration of between 0.5 and 2.0 percent (weight/volume).

3. The anti-infective medical article of claim 1, where the treatment solution further comprises between 0.2 and 1.0 percent (weight/volume) benzalkonium chloride.

4. The anti-infective medical article of claim 2, where the treatment solution further comprises between about 0.25 and 1.0 percent (weight/volume) benzalkonium chloride.

7. The anti-infective medical article of claim 2 where the bismuth salt is bismuth citrate.

8. The anti-infective medical article of claim 4, where the bismuth salt is bismuth citrate.

9. The anti-infective medical article of claim 2, where the bismuth salt is bismuth salicylate.

10. The anti-infective medical article of claim 4, where the bismuth salt is bismuth salicylate.

11. The anti-infective medical article of claim 1, where the chlorhexidine compound is selected from the group consisting of chlorhexidine gluconate, a mixture of chlorhexidine gluconate and chlorhexidine free base, a mixture of chlorhexidine gluconate and chlorhexidine diacetate, a mixture of chlorhexidine gluconate, chlorhexidine free base and chlorhexidine diacetate, and a mixture of chlorhexidine free base and chlorhexidine diacetate.

12. The anti-infective medical article of claim 2, where the chlorhexidine compound is selected from the group consisting of chlorhexidine gluconate, a mixture of chlorhexidine gluconate and chlorhexidine free base, a mixture of chlorhexidine gluconate and chlorhexidine diacetate, a mixture of chlorhexidine gluconate, chlorhexidine free base and chlorhexidine diacetate, and a mixture of chlorhexidine free base and chlorhexidine diacetate.

13. The anti-infective medical article of claim 3, where the chlorhexidine compound is selected from the group consisting of chlorhexidine gluconate, a mixture of chlorhexidine gluconate and chlorhexidine free base, a mixture of chlorhexidine gluconate and chlorhexidine diacetate, a mixture of chlorhexidine gluconate, chlorhexidine free base and chlorhexidine diacetate, and a mixture of chlorhexidine free base and chlorhexidine diacetate.

14. The anti-infective medical article of claim 4, where the chlorhexidine compound is selected from the group consisting of chlorhexidine gluconate, a mixture of chlorhexidine gluconate and chlorhexidine free base, a mixture of chlorhexidine gluconate and chlorhexidine diacetate, a mixture of chlorhexidine gluconate, chlorhexidine free base and chlorhexidine diacetate, and a mixture of chlorhexidine free base and chlorhexidine diacetate.

5. (canceled)

6. (canceled)

15. An anti-infective medical article prepared by exposing a polymer-containing medical article, for an effective period of time, to a treatment solution comprising between 1 and 8 percent (weight/volume)of minocycline, between 1 and 8 percent (weight/volume) of triclosan, and a bismuth salt at a concentration of between 0.5 and 2.0 percent (weight/volume).

16. The anti-infective medical article of claim 15, where the treatment solution further comprises between 0.25 and 1.0 percent (weight/volume) benzalkonium chloride.

19. The anti-infective medical article of claim 15, where the bismuth salt is bismuth citrate.

20. The anti-infective medical article of claim 16, where the bismuth salt is bismuth citrate.

21. The anti-infective medical article of claim 15, where the bismuth salt is bismuth salicylate.

22. The anti-infective medical article of claim 16, where the bismuth salt is bismuth salicylate.

17. (canceled)

18. (canceled)

23. An anti-infective medical article prepared by exposing a polymer-containing medical article, for an effective period of time, to a treatment solution comprising between 1 and 8 percent (weight/volume) of minocycline, between 0.25 and 1.0 percent (weight/volume) of benzalkonium chloride, and between 0.5 and 2.0 percent (weight/volume) of a bismuth salt.

24. The anti-infective medical article of claim 23, where the bismuth salt is selected from the group consisting of bismuth citrate, and bismuth salicylate.

25. An intravascular catheter comprising between 100 and 450 micrograms of minocycline per centimeter and between 130 and 520 micrograms of a chlorhexidine compound.

26. The catheter of claim 25 further comprising between 50 and 300 micrograms per centimeter of a bismuth salt.

27. The catheter of claim 26 where the bismuth salt is selected from the group consisting of bismuth citrate and bismuth salicylate.

28. The catheter of claim 26 further comprising between 25 and 100 micrograms per centimeter of benzalkonium chloride.

29. The catheter of claim 25 where the chlorhexidine compound is selected from the group consisting of chlorhexidine gluconate, a mixture of chlorhexidine gluconate and chlorhexidine free base, a mixture of chlorhexidine gluconate and chlorhexidine diacetate, a mixture of chlorhexidine gluconate, chlorhexidine free base and chlorhexidine diacetate, and a mixture of chlorhexidine free base and chlorhexidine diacetate.

30. The catheter of claim 25 further comprising between 50 and 200 micrograms per centimeter of a zinc salt.

31. The catheter of claim 25 further comprising between 25 and 300 micrograms per centimeter of a silver-containing compound.

32. (canceled)

33. An intravascular catheter comprising between 100 and 450 micrograms of minocycline per centimeter, between 130 and 750 micrograms of triclosan per centimeter, and between 50 and 300 micrograms of a bismuth salt per centimeter.

34. The catheter of claim 33 where the bismuth salt is selected from the group consisting of bismuth citrate and bismuth salicylate.

35. The catheter of claim 33 further comprising between 25 and 100 micrograms per centimeter of benzalkonium chloride.

36. The catheter of claim 33 further comprising between 50 and 200 micrograms per centimeter of a zinc salt.

37. The catheter of claim 33 further comprising between 25 and 300 micrograms per centimeter of a silver-containing compound.

38. (canceled)

39. An anti-infective medical article prepared by exposing a polymer-containing medical article for an effective period of time to a treatment solution comprising between 1 and 8 percent (weight/volume) of minocycline and between 0.5 and 2.0 percent (weight/volume) of a bismuth salt.