Treatment of vascular occlusions using ultrasonic energy and microbubbles
First Claim
1. A method of treating a vascular occlusion located at a treatment site within a patient'"'"'s vasculature, the method comprising:
- passing an ultrasound catheter through the patient'"'"'s vasculature to the treatment site, wherein the ultrasound catheter includes at least one fluid delivery port;
positioning the ultrasound catheter at the treatment site such that the at least one fluid delivery port is positioned within the occlusion;
infusing a microbubble therapeutic compound from the ultrasound catheter into an internal portion of the occlusion without applying ultrasound energy to the site; and
delivering ultrasonic energy from the ultrasound catheter into the infused microbubble therapeutic compound after the vascular occlusion has been infused with the microbubble compound.
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Accused Products
Abstract
In one embodiment of the present invention, a method of treating a vascular occlusion located at a treatment site within a patient'"'"'s vasculature comprises positioning an ultrasound catheter at the treatment site. The method further comprises delivering a microbubble therapeutic compound from the ultrasound catheter to the vascular occlusion during a first treatment phase. The method further comprises pausing the delivery of the microbubble compound and delivering ultrasonic energy from the ultrasound catheter in combination with other therapeutic compounds to the vascular occlusion during a second treatment phase while the delivery of microbubble therapeutic compound remains paused.
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Citations
19 Claims
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1. A method of treating a vascular occlusion located at a treatment site within a patient'"'"'s vasculature, the method comprising:
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passing an ultrasound catheter through the patient'"'"'s vasculature to the treatment site, wherein the ultrasound catheter includes at least one fluid delivery port;
positioning the ultrasound catheter at the treatment site such that the at least one fluid delivery port is positioned within the occlusion;
infusing a microbubble therapeutic compound from the ultrasound catheter into an internal portion of the occlusion without applying ultrasound energy to the site; and
delivering ultrasonic energy from the ultrasound catheter into the infused microbubble therapeutic compound after the vascular occlusion has been infused with the microbubble compound. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method of treating a vascular occlusion located at a treatment site within a patient'"'"'s vasculature, the method comprising:
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positioning an ultrasound catheter at the treatment site;
delivering a microbubble therapeutic compound from the ultrasound catheter to the vascular occlusion during a first treatment phase; and
pausing the delivery of the microbubble therapeutic compound and delivering ultrasound from the ultrasound catheter to the vascular occlusion during a second treatment phase while the delivery of microbubble therapeutic compound remains paused. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method of treating a vascular occlusion located at a treatment site within a patient'"'"'s vasculature, the method comprising:
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passing an ultrasound catheter through the patient'"'"'s vasculature to the treatment site, wherein the ultrasound catheter includes at least one fluid delivery port;
positioning the ultrasound catheter at the treatment site such that the at least one fluid delivery port is positioned within the occlusion; and
alternately infusing a microbubble therapeutic compound from the ultrasound catheter into an internal portion of the occlusion and delivering ultrasonic energy from the ultrasound catheter and other therapeutic compounds to the occlusion.
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Specification