Method for lyophilizing an active agent
First Claim
Patent Images
1. A method for lyophilizing a solution, the method comprising:
- depositing the solution into one or more containers;
positioning a covering plate comprising one or more protuberances projecting from a surface to align with an opening of the one or more containers, the one or more protuberances adapted to fit inside at least a portion of the one or more containers;
covering the one or more containers with the covering plate before placing the one or more containers and the covering plate inside a lyophilizing apparatus or covering the one or more containers with the covering plate after placing the one or more containers and the covering plate inside the lyophilizing apparatus, the one or more projecting protuberances engaged inside the at least a portion of the one or more containers; and
at least partially lyophilizing the solution by cooling the solution and applying a vacuum to the solution, wherein at least partially lyophilizing the solution allows vapor to escape through an annular gap between each of the one or more protuberances and a side wall of each of the one or more containers.
3 Assignments
0 Petitions
Accused Products
Abstract
A process for lyophilizing a solution of an active agent in a container is provided. Solution of active agent is deposited into a container, the container is covered with a covering plate and placed inside a lyophilizing apparatus. Lyophilization can be conducted to dryness by radiation, convection or both. Also provided is a device made by this process, an active agent-plastic administration device (e.g., a syringe), containing an active agent in the form of lyophilized cake, and an array of such administration devices.
-
Citations
20 Claims
-
1. A method for lyophilizing a solution, the method comprising:
-
depositing the solution into one or more containers;
positioning a covering plate comprising one or more protuberances projecting from a surface to align with an opening of the one or more containers, the one or more protuberances adapted to fit inside at least a portion of the one or more containers;
covering the one or more containers with the covering plate before placing the one or more containers and the covering plate inside a lyophilizing apparatus or covering the one or more containers with the covering plate after placing the one or more containers and the covering plate inside the lyophilizing apparatus, the one or more projecting protuberances engaged inside the at least a portion of the one or more containers; and
at least partially lyophilizing the solution by cooling the solution and applying a vacuum to the solution, wherein at least partially lyophilizing the solution allows vapor to escape through an annular gap between each of the one or more protuberances and a side wall of each of the one or more containers. - View Dependent Claims (2, 3, 4, 5, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
-
-
6. The method of claim I wherein covering the one or more containers with the covering plate forms a lid preventing the escape of lyophilizate from the one or more containers during the lyophilization process.
Specification